ArticleNature communications2021
Combined quantum tunnelling and dielectrophoretic trapping for molecular analysis at ultra-low analyte concentrations.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Precise Probing of Interfaces at the Single-Molecule Scale.Nanomaterials (Basel, Switzerland) · 2026Review
- Single-Molecule Conductance of Non-Redox Proteins: Mechanisms, Measurements, and Applications.Biomolecules · 2026Review
- Constructing a Nanopipette-Based DNA Electromechanical Device.Nano letters · 2025Article
- Spatiotemporal molecular tracing of ultralow-volume biofluids via a soft skin-adaptive optical monolithic patch sensor.Nature communications · 2025Article
- Single-Molecule Bioelectronic Sensors with AI-Aided Data Analysis: Convergence and Challenges.Precision chemistry · 2024Review
- Electromigrated Gold Nanogap Tunnel Junction Arrays: Fabrication and Electrical Behavior in Liquid and Gaseous Media.ACS applied materials & interfaces · 2024Article
- In-tube micro-pyramidal silicon nanopore for inertial-kinetic sensing of single molecules.Nature communications · 2024Article
- Semiconducting polymer dots for multifunctional integrated nanomedicine carriers.Materials today. Bio · 2024Review
- Dynamical control of nanoscale light-matter interactions in low-dimensional quantum materials.Light, science & applications · 2024Review
- Fabrication of electron tunneling probes for measuring single-protein conductance.Nature protocols · 2023Review
- Advances in single-molecule junctions as tools for chemical and biochemical analysis.Nature chemistry · 2023Review
- Nanopore Detection Using Supercharged Polypeptide Molecular Carriers.Journal of the American Chemical Society · 2023Article
- Functionalized electrodes embedded in nanopores: read-out enhancement?Chemistry, an Asian journal · 2023Review
- Functional nucleic acid engineered double-barreled nanopores for measuring sodium to potassium ratio at single-cell level.Exploration (Beijing, China) · 2022Article
- Single-Molecule Surface-Enhanced Raman Spectroscopy.Sensors (Basel, Switzerland) · 2022Review
- Controllable Shrinking Fabrication of Solid-State Nanopores.Micromachines · 2022Review
- Measuring conductance switching in single proteins using quantum tunneling.Science advances · 2022Article
- The perspectives of broadband metasurfaces and photo-electric tweezer applications.Nanophotonics (Berlin, Germany) · 2022Review
- A High Spatiotemporal Iontronic Single-Cell Viscometer.Research (Washington, D.C.) · 2022Article
- Sorting Gold and Sand (Silica) Using Atomic Force Microscope-Based Dielectrophoresis.Nano-micro letters · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Quantum tunnelling offers a unique opportunity to study nanoscale objects with atomic resolution using electrical readout. However, practical implementation is impeded by the lack of simple, stable probes, that are required for successful operation. Existing platforms offer low throughput and operate in a limited range of analyte concentrations, as there is no active control to transport molecules to the sensor. We report on a standalone tunnelling probe based on double-barrelled capillary nanoelectrodes that do not require a conductive substrate to operate unlike other techniques, such as scanning tunnelling microscopy. These probes can be used to efficiently operate in solution environments and detect single molecules, including mononucleotides, oligonucleotides, and proteins. The probes are simple to fabricate, exhibit remarkable stability, and can be combined with dielectrophoretic trapping, enabling active analyte transport to the tunnelling sensor. The latter allows for up to 5-orders of magnitude increase in event detection rates and sub-femtomolar sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.