ArticleScience advances2021
Molecular characterization of the human kidney interstitium in health and disease.
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
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Who cites it
33 citing papers in PubMed, 44 citations in OpenAlex.
- Hirsutine mitigates high glucose-induced cell injuryRenal failure · 2026Article
- The kidney stroma in development and disease.Nature reviews. Nephrology · 2025Review
- Vitamin B12 Protects the Exacerbated Ischemia-Reperfusion Injury-Induced Chronic Kidney Disease in Mice with Genetically Increased Elmo1.Antioxidants (Basel, Switzerland) · 2025Article
- Novel insights into kidney disease: the scRNA-seq and spatial transcriptomics approaches: a literature review.BMC nephrology · 2025Review
- Single-cell omics: experimental workflow, data analyses and applications.Science China. Life sciences · 2025Review
- Transcriptomics of SGLT2-positive early proximal tubule segments in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism.American journal of physiology. Renal physiology · 2025Article
- The advance of single cell transcriptome to study kidney immune cells in diabetic kidney disease.BMC nephrology · 2024Review
- Inflammation primes the murine kidney for recovery by activating AZIN1 adenosine-to-inosine editing.The Journal of clinical investigation · 2024Article
- Plasma proteomics of acute tubular injury.Nature communications · 2024Article
- The chromatin landscape of healthy and injured cell types in the human kidney.Nature communications · 2024Article
- Defining the molecular fingerprint of bladder and kidney fibroblasts.American journal of physiology. Renal physiology · 2023Review
- Inflammation primes the kidney for recovery by activating AZIN1 A-to-I editing.bioRxiv : the preprint server for biology · 2023Article
- User-friendly microfluidic system reveals native-like morphological and transcriptomic phenotypes induced by shear stress in proximal tubule epithelium.APL bioengineering · 2023Article
- A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease.Nature communications · 2023Article
- Single-cell transcriptomic profiles in the pathophysiology within the microenvironment of early diabetic kidney disease.Cell death & disease · 2023Article
- Integration of artificial intelligence and multi-omics in kidney diseases.Fundamental research · 2023Review
- Present and future directions in diabetic kidney disease.Journal of diabetes and its complications · 2022Review
- Understanding fibrosis pathogenesis via modeling macrophage-fibroblast interplay in immune-metabolic context.Nature communications · 2022Article
- The interstitium at the developing nephron in the fetal kidney during advanced pregnancy - a microanatomical inventory.Molecular and cellular pediatrics · 2022Article
- A reference tissue atlas for the human kidney.Science advances · 2022Article
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Authors and funding
18 authors at 4 institutions in 1 country.
Daria BarwinskaDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-0776-3030
Tarek M El-AchkarDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. meadon@iupui.edu telachka@iu.edu.ORCID 0000-0003-4645-3614
Ricardo Melo FerreiraDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-2063-9744
Farooq SyedDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-0284-0631
Ying-Hua ChengDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7871-8141
Seth WinfreeDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2396-5871
Michael J FerkowiczDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-9531-3899
Takashi HatoDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-0446-6575
Kimberly S CollinsDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-4978-4593
Kenneth W DunnDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-4245-496X
Katherine J KellyDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7244-9657
Timothy A SuttonDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-4117-1434
Brad H RovinDivision of Nephrology, Department of Medicine, Ohio State University Wexner Medical Center, OH 433210, USA.ORCID 0000-0001-5639-0210
Samir V ParikhDivision of Nephrology, Department of Medicine, Ohio State University Wexner Medical Center, OH 433210, USA.
Carrie L PhillipsDivision of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-0256-0736
Pierre C DagherDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-3321-5561
Michael T EadonDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. meadon@iupui.edu telachka@iu.edu.ORCID 0000-0003-3066-2876
Kidney Precision Medicine Project
Indiana University School of MedicineRichard L. Roudebush VA Medical Center · USThe Ohio State University Wexner Medical Center · USIndiana University – Purdue University Indianapolis · US
Funding
Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4MCentral Hub for Kidney Precision MedicineU24DK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$21.1MConProject-002U2CDK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI KRETZLER, MATTHIAS · 2017 to 2021
$21.0MTranslation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4MPROBE DELIVERY COREP30DK079312 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MOLITORIS, BRUCE A · 2007 to 2021
$17.1MNephron Sub-segmental Omics and Quantitative 3D Imaging of Human Kidney.UH3DK114923 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI ASHKAR, TAREK MAURICE, DAGHER, PIERRE C · 2019 to 2021
$2.2MThe role of antiviral programs in bacterial sepsisR01AI148282 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI HATO, TAKASHI · 2020 to 2024
$2.0MUnderstanding the Function of Tamm-Horsfall Protein in Acute kidney Injury.R01DK111651 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI ASHKAR, TAREK MAURICE · 2017 to 2021
$1.6MModifying kidney injury through p53 signaling.R01DK099345 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DAGHER, PIERRE C, SUTTON, TIMOTHY ALAN · 2014 to 2017
$1.4MCleveland Precision Medicine Chronic Kidney Disease CohortUH3DK114908 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI O'TOOLE, JOHN F., POGGIO, EMILIO DANIEL · 2019 to 2021
$900kAcute inhibition of renal gene expression to prevent nephrotoxicity.K08DK107864 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EADON, MICHAEL THOMAS · 2016 to 2020
$772kModulating purine metabolism to treat kidney injury in sepsis.K08DK113223 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI HATO, TAKASHI · 2017 to 2021
$757kBLRD VA I01 BX002901NIAID NIH HHS R01 AI148282NIDDK NIH HHS K08 DK107864NIDDK NIH HHS K08 DK113223NIDDK NIH HHS P30 DK079312NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK099345NIDDK NIH HHS R01 DK111651NIDDK NIH HHS U24 DK076169NIDDK NIH HHS U24 DK114886NIDDK NIH HHS U2C DK114886NIDDK NIH HHS UH3 DK114908NIDDK NIH HHS UH3 DK114923
Abstract
The gene expression signature of the human kidney interstitium is incompletely understood. The cortical interstitium (excluding tubules, glomeruli, and vessels) in reference nephrectomies (
Indexed as
Diabetic NephropathiesGenes, Tumor SuppressorKidneyFemaleHumansMaleSequence Analysis, RNATranscriptome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.