Evidence map›Paper›PMID 33568457›Full record

ArticlemSphere2021

Glucan Unmasking Identifies Regulators of Temperature-Induced Translatome Reprogramming in C. neoformans.

Amanda L M Bloom, David Goich, Corey M Knowles, John C Panepinto

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Roles of Different Signaling Pathways inJournal of fungi (Basel, Switzerland) · 2024
    Review
  7. Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling inbioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Article
  10. Cell wall composition inFrontiers in fungal biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amanda L M BloomDepartment of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA.
David GoichDepartment of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA.
Corey M KnowlesDepartment of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA.
John C PanepintoDepartment of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA jcp25@buffalo.edu.ORCID 0000-0002-1162-0403
University at Buffalo, State University of New York · US

Funding

Supplement to: Stress Responsive Reprogramming of Translating mRNA Pools in C. neoformansR01AI131977 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI John C Panepinto · 2017 to 2026
$3.6M
NIAID NIH HHS R01 AI131977
6 · The paper itself

Abstract

The cell walls of fungi are critical for cellular structure and rigidity but also serve as a major communicator to alert the cell to the changing environment. In response to stresses encountered in human hosts, pathogenic fungi remodel their cell walls. Masking the β-1,3-glucan component of the cell wall is critical to escape detection by innate immune cells. We previously demonstrated that β-1,3-glucan is unmasked in response to host temperature stress when translatome reprogramming is defective in

Indexed as

Gene Expression Regulation, FungalHot TemperatureCell WallCryptococcus neoformansFungal ProteinsGlucansMitogen-Activated Protein KinasesSignal TransductionFungal ProteinsGlucansMitogen-Activated Protein Kinasescell signalingcell wallCryptococcus neoformansglucanshost evasionstress response

Identifiers

PMID33568457
PMCPMC8544899
OpenAlexW3128319701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.