ArticleAnimal microbiome2021
Ruminal resistome of dairy cattle is individualized and the resistotypes are associated with milking traits.
Article in Animal microbiome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Integrative analysis of rumen microbiota and host multi-organ interactions underlying feed conversion efficiency in Hu sheep.Journal of animal science and biotechnology · 2026Article
- Co-Occurrence Patterns of Bacterial Communities and Resistance Genes: A Comprehensive Multi-Pen Fecal Microbiome and Resistome Study in Dairy Farms.Microorganisms · 2025Article
- Sodium Butyrate Supplementation in Whole Milk Modulates the Gastrointestinal Microbiota Without Altering the Resistome and Virulome in Preweaned Calves.Microorganisms · 2025Article
- Article
- Analysis of the fecal microbiome and metabolome in dairy cows with different body condition scores.PloS one · 2025Article
- Seasonal stability of the rumen microbiome contributes to the adaptation patterns to extreme environmental conditions in grazing yak and cattle.BMC biology · 2024Article
- Fecal microbial gene transfer contributes to the high-grain diet-induced augmentation of aminoglycoside resistance in dairy cattle.mSystems · 2024Article
- Metagenomics reveals the temporal dynamics of the rumen resistome and microbiome in goat kids.Microbiome · 2024Article
- Altered microbiota, antimicrobial resistance genes, and functional enzyme profiles in the rumen of yak calves fed with milk replacer.Microbiology spectrum · 2024Article
- Effect of castration timing and weaning strategy on the taxonomic and functional profile of ruminal bacteria and archaea of beef calves.Animal microbiome · 2023Article
- Interrogating the viral dark matter of the rumen ecosystem with a global virome database.Nature communications · 2023Article
- A review of the predictors of antimicrobial use and resistance in European food animal production.Frontiers in antibiotics · 2023Review
- Citrus flavonoid extracts alter the profiling of rumen antibiotic resistance genes and virulence factors of dairy cows.Frontiers in microbiology · 2023Article
- Expressions of resistome is linked to the key functions and stability of active rumen microbiome.Animal microbiome · 2022Article
- Two chronically misdiagnosed patients infected withFrontiers in cellular and infection microbiology · 2022Article
- A review of the resistome within the digestive tract of livestock.Journal of animal science and biotechnology · 2021Review
- Novel methods of microbiome analysis in the food industry.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Review
- Characterisation of the rumen resistome in Spanish dairy cattle.Animal microbiome · 2021Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundAntimicrobial resistance is one of the most urgent threat to global public health, as it can lead to high morbidity, mortality, and medical costs for humans and livestock animals. In ruminants, the rumen microbiome carries a large number of antimicrobial resistance genes (ARGs), which could disseminate to the environment through saliva, or through the flow of rumen microbial biomass to the hindgut and released through feces. The occurrence and distribution of ARGs in rumen microbes has been reported, revealing the effects of external stimuli (e.g., antimicrobial administrations and diet ingredients) on the antimicrobial resistance in the rumen. However, the host effect on the ruminal resistome and their interactions remain largely unknown. Here, we investigated the ruminal resistome and its relationship with host feed intake and milk protein yield using metagenomic sequencing.
resultsThe ruminal resistome conferred resistance to 26 classes of antimicrobials, with genes encoding resistance to tetracycline being the most predominant. The ARG-containing contigs were assigned to bacterial taxonomy, and the majority of highly abundant bacterial genera were resistant to at least one antimicrobial, while the abundances of ARG-containing bacterial genera showed distinct variations. Although the ruminal resistome is not co-varied with host feed intake, it could be potentially linked to milk protein yield in dairy cows. Results showed that host feed intake did not affect the alpha or beta diversity of the ruminal resistome or the abundances of ARGs, while the Shannon index (R
conclusionsThe current study uncovered the prevalence of ARGs in the rumen of a cohort of lactating dairy cows. The ruminal resistome is not co-varied with host feed intake, while it could be potentially linked to milk protein yield in dairy cows. Our results provide fundamental knowledge on the prevalence, mechanisms and impact factors of antimicrobial resistance in dairy cattle and are important for both the dairy industry and other food animal antimicrobial resistance control strategies.
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