ReviewBiology of sex differences2021
Estrogen receptors in pain modulation: cellular signaling.
Review in Biology of sex differences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 3 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Estrogen Status and Temporomandibular Disorders: A Systematic Review.International journal of environmental research and public health · 2026Pooled it
- The mechanism of different microglial receptors mediating central inflammation in chronic migraine: a meta-analysis.The journal of headache and pain · 2026Pooled it
- Association between Estrogen Levels and Temporomandibular Disorders: An Updated Systematic Review.International journal of molecular sciences · 2024Pooled it
- Trial
- Oestrogen replacement combined with resistance exercise in older women with knee osteoarthritis: a randomised, double-blind, placebo-controlled clinical trial.Age and ageing · 2025Trial
- A Thematic Narrative Review of Osteoarthritis Risk Factors Across the Female Life Course.International journal of molecular sciences · 2026Review
- Four-Dimensional Impact of Oral Behaviours on Oral Health-Related Quality of Life Across TMD Subtypes: A Parallel Multivariate Exploration.Journal of oral rehabilitation · 2026Article
- Muscle-Nerve Signaling and Neurogenic Inflammation in Temporomandibular Disorders: Potential Contributions of Occlusal Interference and Other Peripheral Triggers.Dentistry journal · 2026Review
- Review
- Effect of Preoperative Hormone Replacement Therapy on Postmenopausal Women Undergoing Rotator Cuff Repair.Cureus · 2026Article
- Impact of timing of menopause on musculoskeletal disorders and associated pain in community-dwelling women: the Yakumo study.International orthopaedics · 2026Article
- Article
- Long-term effect of ovary removal on the joints of aged mice.Laboratory animal research · 2026Article
- Review
- Global, regional, and national burden of disease in neck pain: statistical analysis of incidence, prevalence, and DALYS, with projections to 2036.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Sex Differences and Psychological Assessments in Chronic Pain: A Systematic Review and Meta-Analysis.Clinical neuropsychiatry · 2026Article
- Identifying Sex Differences in Adverse Events Reported on Opioid Drugs in the FDA's Adverse Event Reporting System (FAERS).Pharmaceuticals (Basel, Switzerland) · 2026Article
- Features of Changes in Plasma Concentrations of Sex Hormones in Female Rats at Different Stages of Experimental Pain Syndrome in the Maxillofacial Region.Bulletin of experimental biology and medicine · 2026Article
- Daily turmeric and ginger beverage consumption attenuates physical menstrual cycle symptoms in sub-elite female footballers: a pilot study.Physical activity and nutrition · 2026Article
- Sex differences in pain in 2 large and diverse US databases.Pain reports · 2026Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Sensory perception and emotional disorders are disproportionally represented in men and women and are thus thought to be modulated by different sex hormones in various conditions. Among the most important hormones perceived to affect sensory processing and transduction is estrogen. Numerous previous researchers have endeavored to demonstrate that estrogen is capable of modulating the activity of sensory neurons in peripheral and central sites in female, male, or castrated animals. However, the underlying mechanisms of its modulation of neuronal activity are somewhat unclear. In the present review, we discuss the possible cellular and molecular mechanisms involved in the modulation of nociception by estrogen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.