Evidence map›Paper›PMID 33568190›Full record

Trial reportRadiation oncology (London, England)2021

Pattern of failure in prostate cancer previously treated with radical prostatectomy and post-operative radiotherapy: a secondary analysis of two prospective studies using novel molecular imaging techniques.

Lindsay S Rowe, Stephanie Harmon, Adam Horn, Uma Shankavaram, Soumyajit Roy, Holly Ning, Liza Lindenberg, Esther Mena, Deborah E Citrin, Peter Choyke and 1 more

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Radiation oncology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Lindsay S RoweRadiation Oncology Branch, National Cancer Institute, 10 Center Drive Magnuson Clinical Center, Room B2-3500, Bethesda, MD, 20892, USA. Lindsay.rowe@albertahealthservices.ca.ORCID http://orcid.org/0000-0002-7980-0996
Stephanie HarmonClinical Research Directorate, Frederick National Laboratory for Cancer Research, 10 Center Drive Magnuson Clinical Center, Room B3B69F, Bethesda, MD, 20892, USA.
Adam HornWalter Reed National Military Medical Center, Bethesda, MD, 8901 Rockville Pike, USA.
Uma ShankavaramRadiation Oncology Branch, National Cancer Institute, 10 Center Drive Magnuson Clinical Center, Room 1002, Bethesda, MD, 20892, USA.
Soumyajit RoyRadiation Oncology Branch, National Cancer Institute, 10 Center Drive Magnuson Clinical Center, Room B2-3500, Bethesda, MD, 20892, USA.
Holly NingRadiation Oncology Branch, National Cancer Institute, 10 Center Drive Magnuson Clinical Center, Room B2-3500, Bethesda, MD, 20892, USA.
Liza LindenbergMolecular Imaging Program, National Cancer Institute, 10 Center Drive Magnuson Clinical Center, Room B3B69F, Bethesda, MD, 20892, USA.
Esther MenaMolecular Imaging Program, National Cancer Institute, 10 Center Drive Magnuson Clinical Center, Room B3B69F, Bethesda, MD, 20892, USA.
Deborah E CitrinRadiation Oncology Branch, National Cancer Institute, 10 Center Drive Magnuson Clinical Center, Room B2-3500, Bethesda, MD, 20892, USA.
Peter ChoykeMolecular Imaging Program, National Cancer Institute, 10 Center Drive Magnuson Clinical Center, Room B3B69F, Bethesda, MD, 20892, USA.
Baris TurkbeyMolecular Imaging Program, National Cancer Institute, 10 Center Drive Magnuson Clinical Center, Room B3B69F, Bethesda, MD, 20892, USA.
National Cancer Institute · USFrederick National Laboratory for Cancer Research · USUniversity of Alberta · CAWalter Reed National Military Medical Center · US

Funding

Radiation Oncology Branch - Radiation ClinicZIDBC010990 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CAMPHAUSEN, KEVIN · 2009 to 2025
$136.0M
Prostate Cancer ImagingZIABC010655 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2025
$49.2M
Targeting mechanisms of radiation resistanceZIABC011552 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CITRIN, DEBORAH · 2014 to 2025
$12.2M
Imaging, image guided biopsy and treatment of prostate cancerZIABC012062 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TÜRKBEY, BARIS · 2021 to 2025
$1.3M
Intramural NIH HHS ZID BC010990NCI NIH HHS ZID BC 010990
6 · The paper itself

Abstract

backgroundProstate Membrane Specific Antigen (PSMA) positron emission tomography (PET) and multiparametric MRI (mpMRI) have shown high accuracy in identifying recurrent lesions after definitive treatment in prostate cancer (PCa). In this study, we aimed to outline patterns of failure in a group of post-prostatectomy patients who received adjuvant or salvage radiation therapy (PORT) and subsequently experienced biochemical recurrence, using

methodsPCa patients with biochemical failure post-prostatectomy, and no evident site of recurrence on conventional imaging, were enrolled on two prospective trials of first and second generation

resultsA total of 34 participants underwent

conclusions

Indexed as

AgedAntigens, SurfaceCombined Modality TherapyFollow-Up StudiesGlutamate Carboxypeptidase IIHumansMaleMiddle AgedMolecular ImagingNeoplasm Recurrence, LocalPositron-Emission TomographyProspective StudiesProstatectomyProstatic NeoplasmsRadiotherapyRetrospective StudiesAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IIBiochemical recurrenceF-18PET/CTProstate cancerProstatectomyProstate-specific membrane antigen (PSMA)Radiation therapy

Identifiers

PMID33568190
PMCPMC7874470
OpenAlexW3126366333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.