Evidence map›Paper›PMID 33568153›Full record

ArticleThrombosis journal2021

Autopsy and statistical evidence of disturbed hemostasis progress in COVID-19: medical records from 407 patients.

Tiebin Jiang, Bo Lv, Hongxia Liu, Shiwen He, Guogang Zhang, Chanyi Li, Wanqiong Li, Weilin Li, Yaqi He, Tong Zhang and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Fibrinolytic system and COVID-19: From an innovative view of epithelial ion transport.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
    Review
  3. Comparison of acute respiratory distress syndrome in patients with COVID-19 and influenza A (H7N9) virus infection.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 1 country.

Tiebin Jiang *Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Bo Lv *Department of Regenerative Medicine, School of Medicine, Tongji University, 1239 Siping Road, Shanghai, 200092, China.
Hongxia Liu *Scientometrics and Evaluation Center for Rule of Law, China University of Political Science and Law, Beijing, 100088, China.
Shiwen He *School of Computer Science and Engineering, Central South University, Changsha, 410083, China.
Guogang Zhang *Department of Cardiovascular, The Third Xiangya Hospital, The Central South University, Changsha, 410013, Hunan, China.
Chanyi LiDepartment of Regenerative Medicine, School of Medicine, Tongji University, 1239 Siping Road, Shanghai, 200092, China.
Wanqiong LiReproductive Medicine Center, Tongji Hospital, Tongji University, Shanghai, 200065, China.
Weilin LiStem Cell and Regenerative Medicine Engineering Research Center of Hunan Province, Hunan Yuanpin Cell Technology Co. Ltd, 102 Dongwu Road, Changsha City, 410100, Hunan Province, China.
Yaqi HeSchool of Computer Science and Engineering, Central South University, Changsha, 410083, China.
Tong ZhangSchool of Computer Science and Engineering, Central South University, Changsha, 410083, China.
Yunyun WangDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan City, 430030, Hubei Province, China.
Wu MoStem Cell and Regenerative Medicine Engineering Research Center of Hunan Province, Hunan Yuanpin Cell Technology Co. Ltd, 102 Dongwu Road, Changsha City, 410100, Hunan Province, China.
Ning YiStem Cell and Regenerative Medicine Engineering Research Center of Hunan Province, Hunan Yuanpin Cell Technology Co. Ltd, 102 Dongwu Road, Changsha City, 410100, Hunan Province, China.
Luying PengDepartment of Regenerative Medicine, School of Medicine, Tongji University, 1239 Siping Road, Shanghai, 200092, China.
Ying LiDepartment of Hematology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Chunhong RuanDepartment of Hematology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Chengyuan LiDepartment of Hematology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Yaqi LiuDepartment of Hematology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Peipei LuoDepartment of Hematology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Huan JiangDepartment of Hematology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Zhigang XueDepartment of Regenerative Medicine, School of Medicine, Tongji University, 1239 Siping Road, Shanghai, 200092, China. xuezg@tongji.edu.cn.ORCID http://orcid.org/0000-0001-7715-1403
Liang LiuDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan City, 430030, Hubei Province, China. 907505@qq.com.
Wenjun WangStem Cell and Regenerative Medicine Engineering Research Center of Hunan Province, Hunan Yuanpin Cell Technology Co. Ltd, 102 Dongwu Road, Changsha City, 410100, Hunan Province, China. wwj1202@hotmail.com.
Central South University · CNTongji University · CNCell Technology (China) · CNHuazhong University of Science and Technology · CNChina University of Political Science and Law · CN

Funding

Key Research and Development Plan of Hunan Province 2020SK3015National Science Foundation of China 81771651National Science Foundation of China 81871820the National Key R&D Program of China 2016YFC1000208the National Key R&D Program of China 2017YFC1001301
6 · The paper itself

Abstract

backgroundThe progression of coagulation in COVID-19 patients with confirmed discharge status and the combination of autopsy with complete hemostasis parameters have not been well studied.

objectiveTo clarify the thrombotic phenomena and hemostasis state in COVID-19 patients based on epidemiological statistics combining autopsy and statistical analysis.

methodsUsing autopsy results from 9 patients with COVID-19 pneumonia and the medical records of 407 patients, including 39 deceased patients whose discharge status was certain, time-sequential changes in 11 relevant indices within mild, severe and critical infection throughout hospitalization according to the Chinese National Health Commission (NHC) guidelines were evaluated. Statistical tools were applied to calculate the importance of 11 indices and the correlation between those indices and the severity of COVID-19.

resultsAt the beginning of hospitalization, platelet (PLT) counts were significantly reduced in critically ill patients compared with severely or mildly ill patients. Blood glucose (GLU), prothrombin time (PT), activated partial thromboplastin time (APTT), and D-dimer levels in critical patients were increased compared with mild and severe patients during the entire admission period. The International Society on Thrombosis and Haemostasis (ISTH) disseminated intravascular coagulation (DIC) score was also high in critical patients. In the relatively late stage of nonsurvivors, the temporal changes in PLT count, PT, and D-dimer levels were significantly different from those in survivors. A random forest model indicated that the most important feature was PT followed by D-dimer, indicating their positive associations with disease severity. Autopsy of deceased patients fulfilling diagnostic criteria for DIC revealed microthromboses in multiple organs.

conclusionsCombining autopsy data, time-sequential changes and statistical methods to explore hemostasis-relevant indices among the different severities of the disease helps guide therapy and detect prognosis in COVID-19 infection.

Indexed as

AutopsyCOVID-19HemostasisStatisticsThrombosis

Identifiers

PMID33568153
PMCPMC7873516
OpenAlexW3118087015

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.