SynthesisBMC ophthalmology2021
The effect of diabetes on corneal endothelium: a meta-analysis.
Synthesis in BMC ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of corneal endothelial changes after phacoemulsification in diabetic and non-diabetic patients.BMC ophthalmology · 2023Pooled it
- Association of Systemic and Ocular Comorbidities with Visual Recovery in Patients with Postoperative Corneal Oedema: A Real-World Study of Cataract Surgery Outcomes.Journal of clinical medicine · 2026Article
- Metabolic and redox adaptations of the corneal endothelium: From metabolic plasticity to therapeutic opportunities.Redox biology · 2026Review
- Influence of chronic hyperglycemia on corneal endothelium structural integrity with emphasis on hexagonality.International ophthalmology · 2026Observational
- Article
- Diabetic keratopathy and nuclear proteins (Review).Molecular medicine reports · 2026Review
- Comparative study of corneal endothelial morphology and central corneal thickness in diabetic and non-diabetic patients at tertiary care centre.BMC ophthalmology · 2025Article
- Evaluation of corneal densitometry using Pentacam in patients with type 2 diabetes mellitus: a controlled cross-sectional study.BMC ophthalmology · 2025Article
- Corneal Endothelial Changes After Phacoemulsification Using the Eight-Chop Technique in Diabetic Eyes.Journal of personalized medicine · 2025Article
- The prevalence of corneal guttata and its related risk factors in a Thai population: a community-based study in central Thailand.Scientific reports · 2025Article
- The Role of Immune Cells and Signaling Pathways in Diabetic Eye Disease: A Comprehensive Review.Biomedicines · 2024Review
- Effects of kaempherol-3-rhamnoside on metabolic enzymes and AMPK in the liver tissue of STZ-induced diabetes in mice.Scientific reports · 2024Article
- Unaddressed Factors and Their Role in Descemet Membrane Endothelial Keratoplasty Outcomes: Comments on "Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Using a Preloaded Imported Graft".Korean journal of ophthalmology : KJO · 2024Article
- Diabetic Keratopathy: Redox Signaling Pathways and Therapeutic Prospects.Antioxidants (Basel, Switzerland) · 2024Review
- The impact of donor diabetes on corneal transplant immunity.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- Assessment of corneal endothelial cell parameters using specular microscopy in previously infected SARS-CoV-2 patients.International ophthalmology · 2023Review
- Evaluation of corneal backward light scattering in type 2 diabetes mellitus.International journal of ophthalmology · 2023Article
- Type 2 Diabetes Mellitus Makes Corneal Endothelial Cells Vulnerable to Ultraviolet A-Induced Oxidative Damage Via Decreased DJ-1/Nrf2/NQO1 Pathway.Investigative ophthalmology & visual science · 2022Article
- Risk factors for fluctuations in corneal endothelial cell density (Review).Experimental and therapeutic medicine · 2022Review
- Corneal Endothelial Characteristics in Normal Chinese Han Children and Youngsters: A Study from the Specular Microscopy Descriptions.Disease markers · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThis research was conducted with the aim to determine the effect of diabetes mellitus on corneal endothelial cells.
methodsThe terms: ("diabetes mellitus" or "diabetes" or "diabetic") and ("corneal endothelium" or "cornea" or "Corneas") searched in Pubmed, Embase, Cochrane, and Web of science until August 2019. The included types of studies contained observational studies. The standard mean difference (SMD) which was deemed as main size effects for continuous data was calculated by means and standard deviations. The data on corneal endothelial cell density (ECD), mean cell area (MCA), cell area variation coefficient (CV) and percentage of hexagonal cells (HEX) included in the study were collected and analyzed using stata15.1.
resultsThe final 16 cross-sectional studies and 2 case-control studies were included for the meta-analysis. Meta-analysis revealed that diabetes mellitus could reduce ECD (SMD = - 0.352, 95% CI -0.538, - 0.166) and the HEX (SMD = - 0.145, 95% CI -0.217, - 0.074), in addition to increasing CV (SMD = 0.195, 95% CI 0.123, 0.268). Nevertheless, there was no statistically significant differences observed when combining MCA (SMD = 0.078, 95% CI -0.022, 0.178). In subgroup analysis, Type 2 diabetes patients owned less corneal ECD (P < 0.05). Moreover the same results also found during the subgroup form Asia, Europe and American. The meta-regression revealed the type of diabetes mellitus might be contributing to heterogeneity. (P = 0.008). The results indicated a significant publication bias for studies, with combined CV (Begg's test, P = 0.006; Egger's test, P = 0.005) and merged combined HEX (Begg's test, P = 0.113; Egger's test, P = 0.024).
conclusionsAs indicated by meta-analysis, diabetes mellitus could cause a detrimental effect on corneal endothelium health. Diabetes mellitus contributed to the instability of corneal endothelium during the analysis. Therefore, further research is considered necessary to confirm our research results.
trial registrationCED 42019145858 .
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