Evidence map›Paper›PMID 33567868›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans.

Stefan Haemmig, Ali Hashemi Gheinani, Marina Zaromytidou, Gerasimos Siasos, Ahmet Umit Coskun, Michelle A Cormier, David A Gross, A K M Khyrul Wara, Antonios P Antoniadis, Xinghui Sun and 10 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 3 countries.

Stefan Haemmig *Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Ali Hashemi Gheinani *Department of Surgery, Urological Diseases Research Center, Boston Children Hospital (A.H.G.), Harvard Medical School, Boston, MA.
Marina ZaromytidouDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Gerasimos SiasosDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Ahmet Umit CoskunDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Michelle A CormierDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
David A GrossDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
A K M Khyrul WaraDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Antonios P AntoniadisDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Xinghui SunDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Galina K SukhovaDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Fred G P WeltDivision of Cardiovascular Medicine, University of Utah Health Sciences Center, Salt Lake City (F.G.P.W.).
Ioannis AndreouDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Carl WhatlingBioscience Cardiovascular/Early Clinical Development/Translational Science and Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden (C.W., L.-M.G., J.W.).
Li-Ming GanBioscience Cardiovascular/Early Clinical Development/Translational Science and Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden (C.W., L.-M.G., J.W.).
Johannes Wikström
Elazer R EdelmanDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Peter LibbyDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Peter H StoneDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Mark W FeinbergDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Brigham and Women's Hospital · USAstraZeneca (Finland) · FIBroad Institute · USUniversity of Utah · US

Funding

Vascular Drug Delivery - Supplement for EquipmentR01GM049039 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI EDELMAN, ELAZER R · 1994 to 2019
$8.9M
MiR-181b, endothelial cells, and vascular inflammationR01HL115141 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEINBERG, MARK W · 2012 to 2024
$6.8M
miR-615, AKT/eNOS signaling, and angiogenesisR01HL148207 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEINBERG, MARK W · 2020 to 2023
$2.6M
LncRNA SNHG12, vascular senescence, and atherosclerosisR01HL148355 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEINBERG, MARK W · 2020 to 2023
$2.5M
Novel mechanisms of the thrombotic complications of atherosclerosisR01HL134892 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2019 to 2022
$1.7M
KLF10, CD4+ T cells, and transplant arteriopathyR01HL134849 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEINBERG, MARK W · 2017 to 2020
$1.7M
LncRNA MAARS, macrophage apoptosis, and atherosclerosisR01HL153356 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEINBERG, MARK W · 2020 to 2023
$1.7M
NHLBI NIH HHS R01 HL115141NHLBI NIH HHS R01 HL134849NHLBI NIH HHS R01 HL134892NHLBI NIH HHS R01 HL148207NHLBI NIH HHS R01 HL148355NHLBI NIH HHS R01 HL153356NIGMS NIH HHS R01 GM049039
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Gene Expression ProfilingPlaque, AtheroscleroticTranscriptomeAgedAged, 80 and overAnimalsCarotid Artery DiseasesCoronary Artery DiseaseDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Disease ProgressionFemaleGene Expression RegulationGene Regulatory NetworksHumansHypercholesterolemiaalgorithmsatherosclerosiscoronary vesselsmitochondriatechnology

Identifiers

PMID33567868
PMCPMC7990701
OpenAlexW3126333130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.