Evidence map›Paper›PMID 33567867›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Platelet Dysfunction During Mechanical Circulatory Support: Elevated Shear Stress Promotes Downregulation of α

Yana Roka-Moiia, Samuel Miller-Gutierrez, Daniel E Palomares, Joseph E Italiano, Jawaad Sheriff, Danny Bluestein, Marvin J Slepian

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Platelet Disorders and Medication Strategies.Thrombosis and haemostasis · 2026
    Review
  5. Key markers and detection methods for evaluating platelet dysfunction in mechanical circulatory support devices.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Review
  6. Feasibility and Safety of Cytosorb Application in Patients With Acute Liver Failure.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  7. Observational
  8. Review
  9. Enhanced Hemocompatibility via Bivalirudin and Bicarbonate as Alternative to Heparin in a Catheter-Based Axial-Flow System.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Article
  10. Targeting platelet-tumor cell interactions: a novel approach to cancer therapy.Medical oncology (Northwood, London, England) · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yana Roka-MoiiaDepartment of Medicine (Y.R.-M., S.M.-G.), Sarver Heart Center, University of Arizona, Tucson.
Samuel Miller-GutierrezDepartment of Medicine (Y.R.-M., S.M.-G.), Sarver Heart Center, University of Arizona, Tucson.
Daniel E PalomaresDepartment of Biomedical Engineering (D.E.P., M.J.S.), Sarver Heart Center, University of Arizona, Tucson.
Joseph E ItalianoBrigham and Woman's Hospital, Harvard Medical School, Boston, MA (J.E.I.).
Jawaad SheriffDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY (J.S., D.B., M.J.S.).
Danny BluesteinDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY (J.S., D.B., M.J.S.).
Marvin J SlepianDepartment of Biomedical Engineering (D.E.P., M.J.S.), Sarver Heart Center, University of Arizona, Tucson.
University of Arizona · USStony Brook University · USWoman's Hospital · US

Funding

Optimizing Cardiovascular Device Thromboresistance for Eliminating AnticoagulantsU01EB012487 · NIBIB · STATE UNIVERSITY NEW YORK STONY BROOK · PI BLUESTEIN, DANNY · 2010 to 2014
$6.9M
Multiscale Modeling of Blood Flow and Platelet Mediated ThrombosisU01HL131052 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI BLUESTEIN, DANNY · 2016 to 2020
$3.6M
NHLBI NIH HHS U01 HL131052NIBIB NIH HHS U01 EB012487
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Mechanotransduction, CellularPlatelet AggregationAdenosine DiphosphateBlood PlateletsCell-Derived MicroparticlesDown-RegulationFemaleHumansMaleOligopeptidesPlatelet Glycoprotein GPIb-IX ComplexPlatelet Glycoprotein GPIIb-IIIa ComplexP-SelectinStress, MechanicalAdenosine DiphosphateOligopeptidesPlatelet Glycoprotein GPIb-IX ComplexPlatelet Glycoprotein GPIIb-IIIa ComplexP-SelectinSELP protein, humanSer-Phe-Phe-Leu-Arg-Asnadhesion receptorflow cytometryheart failureplatelet aggregationthrombosis

Identifiers

PMID33567867
PMCPMC8179715
OpenAlexW3126637759

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.