Evidence map›Paper›PMID 33567773›Full record

ReviewInternational journal of molecular sciences2021

Plasminogen Receptors and Fibrinolysis.

Lindsey A Miles, Lina Ny, Malgorzata Wilczynska, Yue Shen, Tor Ny, Robert J Parmer

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Lindsey A MilesDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-0368-0895
Lina NyDepartment of Medical Biochemistry and Biophysics, Umeå University, 90187 Umeå, Sweden.
Malgorzata WilczynskaDepartment of Medical Biochemistry and Biophysics, Umeå University, 90187 Umeå, Sweden.
Yue ShenDepartment of Medical Biochemistry and Biophysics, Umeå University, 90187 Umeå, Sweden.
Tor NyDepartment of Medical Biochemistry and Biophysics, Umeå University, 90187 Umeå, Sweden.
Robert J ParmerDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA and Veterans Administration San Diego Healthcare System, San Diego, CA 92161, USA.
Umeå University · SEScripps Research Institute · USUniversity of California San Diego · US

Funding

Regulation of plasminogen-dependent cell functions by the novel receptor, Plg-RKTR01HL081046 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI MILES, LINDSEY A · 2007 to 2024
$8.7M
A Novel Plasminogen Receptor Promotes Adipose Function and Metabolic HomeostasisR01HL149511 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI MILES, LINDSEY A, PARMER, ROBERT J · 2019 to 2022
$3.0M
Distinguishing plasminogen-dependent and plasminogen-independent roles of the plasminogen receptor, Plg-RKTR21HD101133 · NICHD · SCRIPPS RESEARCH INSTITUTE, THE · PI MILES, LINDSEY A · 2020 to 2021
$488k
Regulation of Renal Injury and Fibrosis by the Plasminogen Receptor, Plg-RKTI01BX003933 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI PARMER, ROBERT J · 2018 to 2021
–
BLRD VA I01 BX003933CSRD VA 1NHLBI NIH HHS R01 HL081046NHLBI NIH HHS R01 HL149511NICHD NIH HHS R21 HD101133NIH HHS HD101133NIH HHS HL081046NIH HHS HL149511U.S. Department of Veterans Affairs I01BX003933
6 · The paper itself

Abstract

The ability of cells to promote plasminogen activation on their surfaces is now well recognized, and several distinct cell surface proteins have been demonstrated to function as plasminogen receptors. Here, we review studies demonstrating that plasminogen bound to cells, in addition to plasminogen directly bound to fibrin, plays a major role in regulating fibrin surveillance. We focus on the ability of specific plasminogen receptors on eukaryotic cells to promote fibrinolysis in the in vivo setting by reviewing data obtained predominantly in murine models. Roles for distinct plasminogen receptors in fibrin surveillance in intravascular fibrinolysis, immune cell recruitment in the inflammatory response, wound healing, and lactational development are discussed.

Indexed as

FibrinolysisAnimalsFibrinHumansPlasminogenReceptors, Cell SurfaceFibrinPlasminogenReceptors, Cell Surfacefibrinolysisplasminogenplasminogen receptors

Identifiers

PMID33567773
PMCPMC7914795
OpenAlexW3127652098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.