ArticleInternational journal of molecular sciences2021
Impact of Liposomal Drug Formulations on the RBCs Shape, Transmembrane Potential, and Mechanical Properties.
Sylwia Cyboran-Mikołajczyk, Przemysław Sareło, Robert Pasławski, Urszula Pasławska, Magdalena Przybyło, Kacper Nowak, Michał Płóciennik, Halina Podbielska, Marta Kopaczyńska, Magdalena Wawrzyńska
Open access · goldAbstract read
In one paragraphArticle in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors at 4 institutions in 1 country.
Sylwia Cyboran-MikołajczykDepartment of Physics and Biophysics, Faculty of Life Sciences and Technology, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.
Przemysław SarełoDepartment of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.ORCID 0000-0002-9125-7594 Robert PasławskiDepartment of Veterinary Surgery, Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, Gagarina 11, 87-100 Toruń, Poland.ORCID 0000-0002-9607-2919 Urszula PasławskaDepartment of Diagnostics and Clinical Sciences, Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, Gagarina 11, 87-100 Toruń, Poland.ORCID 0000-0003-2298-9713 Magdalena PrzybyłoDepartment of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.
Kacper NowakDepartment of Internal Diseases and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.
Michał PłóciennikDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.ORCID 0000-0002-5680-3246 Halina PodbielskaDepartment of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.ORCID 0000-0001-7162-8530 Marta KopaczyńskaDepartment of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.
Magdalena WawrzyńskaDepartment of Preclinical Studies, Faculty of Health Sciences, Wrocław Medical University, Wybrzeże Paustera 1, 50-367 Wrocław, Poland.
Wrocław University of Science and Technology · PLWrocław University of Environmental and Life Sciences · PLNicolaus Copernicus University · PLWroclaw Medical University · PL
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Liposomal technologies are used in order to improve the effectiveness of current therapies or to reduce their negative side effects. However, the liposome-erythrocyte interaction during the intravenous administration of liposomal drug formulations may result in changes within the red blood cells (RBCs). In this study, it was shown that phosphatidylcholine-composed liposomal formulations of Photolon, used as a drug model, significantly influences the transmembrane potential, stiffness, as well as the shape of RBCs. These changes caused decreasing the number of stomatocytes and irregular shapes proportion within the cells exposed to liposomes. Thus, the reduction of anisocytosis was observed. Therefore, some nanodrugs in phosphatidylcholine liposomal formulation may have a beneficial effect on the survival time of erythrocytes.
Indexed as
Membrane PotentialsAnimalsCell ShapeChlorophyllidesDrug CompoundingErythrocytesFemaleHemolysisLiposomesPhosphatidylcholinesPorphyrinsRadiation-Sensitizing AgentsSwineChlorophyllidesLiposomesPhosphatidylcholinesphytochlorinPorphyrinsRadiation-Sensitizing Agentsanisocytosisbiomechanical propertiesdrug carriermonolayer liposome formulationsosmotic resistancephosphatidylcholine liposomesPhotolonshape of erythrocytestransmembrane potential
Identifiers
PMID33567766
PMCPMC7914935
OpenAlexW3128763618
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