ArticleMolecules (Basel, Switzerland)2021
Chemical Composition, Apoptotic Activity, and Antiparasitic Effects of
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Thymol and Carvacrol Against Echinococcus spp.: Experimental Evidence, Mechanistic Insights, and Translational Perspectives.Acta parasitologica · 2026Review
- Antiparasitic efficacy of geraniol from Apiaceae family in scabies treatment.Scientific reports · 2025Article
- Therapeutic Effects of Green Synthesized Copper Nanoparticles Against Hydatid Disease Through Inhibiting Inflammation, Oxidative Stress, and Apoptosis.Acta parasitologica · 2025Article
- Rhanterium Epapposum Essential Oil and Its Primary Compounds Control Infection, Inflammation, and Serum Electrolyte Imbalance in Mice with Giardiasis.Acta parasitologica · 2025Article
- Article
- Potential activity ofFrontiers in pharmacology · 2025Article
- Phytochemical Screening, Protoscolicidal Activity and Mechanisms of Action ofArchives of Razi Institute · 2024Article
- Antileishmanial and synergic effects of Rhanterium epapposum essential oil and its main compounds alone and combined with glucantime against Leishmania major infection.International journal for parasitology. Drugs and drug resistance · 2024Article
- High potency of linalool-zinc oxide nanocomposite as a new agent for cystic echinococcosis treatment.Antimicrobial agents and chemotherapy · 2024Article
- Wound healing activity of green synthesized copper nanoparticles through cell proliferation-migration, antimicrobial effects, and nitric oxide triggering.Archives of Razi Institute · 2024Article
- Comparison of the Scolicidal Activity of Two Leaves Extracts of Myrtus communis from Algeria Against Echinococcus granulosus Sensu Lato Protoscoleces.Acta parasitologica · 2024Article
- Anti-Cancer Effects of Queen Bee Acid (10-Hydroxy-2-Decenoic Acid) and Its Cellular Mechanisms against Human Hepatoma Cells.Molecules (Basel, Switzerland) · 2023Article
- Chemical composition, antileishmanial, and cytotoxic effectsParasite epidemiology and control · 2022Article
- Effects of green synthesized zinc nanoparticles alone and along with albendazole against hydatid cyst protoscoleces.Annals of medicine and surgery (2012) · 2022Article
- Herbal Medicines against Hydatid Disease: A Systematic Review (2000-2021).Life (Basel, Switzerland) · 2022Review
- Acaricidal, Larvacidal, and Repellent Activity ofPlants (Basel, Switzerland) · 2022Article
- Antiparasitic effects ofSaudi journal of biological sciences · 2022Article
- Therapeutic Potential and Safety of theFrontiers in cellular and infection microbiology · 2022Article
- Discrimination of the Essential Oils Obtained from Four Apiaceae Species Using Multivariate Analysis Based on the Chemical Compositions and Their Biological Activity.Plants (Basel, Switzerland) · 2021Article
- In vitro and in vivo Anti-Infection and drug resistance · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundToday, the present protoscolicidals used to minimize the serious risks during hydatid cyst surgery are not completely safe and have various adverse side effects. The present study aimed to evaluate the chemical composition and apoptotic activity of
methodsGas chromatography/mass spectrometry (GC/MS) analysis was performed to determine the chemical composition of FMEO. Protoscoleces of hydatid cysts were collected from liver fertile hydatid cysts of infected sheep and were then treated with various concentrations of the essential oil (75, 150, and 300 µL/mL) for 5-60 min in vitro and ex vivo. Then, by using the eosin exclusion test, the viability of the protoscoleces was studied. The caspase-3-like activity of the FMEO-treated protoscoleces was also evaluated through the colorimetric protease assay Sigma Kit based on the manufacturer's instructions.
resultsAccording to GC/MS, the main constituents of the essential oil were terpinolene (77.72%), n-nonanal (4.47%), and linalool (4.35%), respectively. In vitro, the maximum protoscolicidal activity of FMEO was observed at the concentrations of 150 and 300 µL/mL, such that 100% of the protoscoleces were killed after 30 and 20 min of exposure, respectively. Based on the obtained findings, the results demonstrate that FMEO required a longer time to kill protoscoleces ex vivo; after 12 min of exposure to FMEO, only 13.4% of the protoscoleces remained alive. After 48 h of the treatment of protoscoleces, FMEO, in a dose-dependent manner and at doses of 75, 150, and 300 µL/mL, induced the activation of the caspase enzyme by 24.3, 35.3, and 48.3%, respectively.
conclusionsOur findings demonstrate the potent protoscolicidal effects of FMEO in vitro and ex vivo; however, further studies are required to assess the safety and the efficiency of FMEO as a promising scolicidal agent in a preclinical model and clinical setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.