Evidence map›Paper›PMID 33567541›Full record

ArticleCancers2021

Recurrent Somatic Chromosomal Abnormalities in Relapsed Extraocular Retinoblastoma.

Rosario Aschero, Jasmine H Francis, Daiana Ganiewich, Soledad Gomez-Gonzalez, Claudia Sampor, Santiago Zugbi, Daniela Ottaviani, Lauriane Lemelle, Marcela Mena, Ursula Winter and 13 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Targeting GPC2 on Intraocular and CNS Metastatic Retinoblastomas with Local and Systemic Delivery of CAR T Cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  5. Article
  6. Article
  7. The importance of basic and translational research in caring for children with malignant solid tumors in Latin America.Revista panamericana de salud publica = Pan American journal of public health · 2024
    Review
  8. Article
  9. Article
  10. Special Issue ofCancers · 2023
    Article
  11. Article
  12. Article
  13. Retinoblastoma: Review and new insights.Frontiers in oncology · 2022
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 4 countries.

Rosario AscheroPathology Service, Hospital de Pediatría JP Garrahan, Buenos Aires 1245, Argentina.ORCID 0000-0001-5971-3417
Jasmine H FrancisOphthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Daiana GaniewichLaboratory of Molecular and Cellular Therapy, Instituto Leloir-Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA), Buenos Aires 1405, Argentina.
Soledad Gomez-GonzalezDevelopmental Tumor Biology Laboratory, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.ORCID 0000-0002-0578-4276
Claudia SamporHematology-Oncology Service, Hospital de Pediatría JP Garrahan, Buenos Aires 1245, Argentina.
Santiago ZugbiNational Scientific and Technical Research Council, CONICET, Buenos Aires 1425, Argentina.
Daniela OttavianiUniversity of Paris and Institut Curie (SIREDO Center: Care, Innovation and Reserach in pediatric, Adolescent and Young Adults Oncology), CNRS, UMR144, Equipe Labellisée Ligue Contre le Cancer, 75005 Paris, France.
Lauriane LemelleUniversity of Paris and Institut Curie (SIREDO Center: Care, Innovation and Reserach in pediatric, Adolescent and Young Adults Oncology), CNRS, UMR144, Equipe Labellisée Ligue Contre le Cancer, 75005 Paris, France.
Marcela MenaInnovative Treatments Unit, Hospital de Pediatría JP Garrahan, Buenos Aires 1245, Argentina.
Ursula WinterPathology Service, Hospital de Pediatría JP Garrahan, Buenos Aires 1245, Argentina.
Genoveva Correa LlanoPediatric Hematology and Oncology, Hospital Sant Joan de Déu, 08950 Barcelona, Spain.ORCID 0000-0002-8604-9862
Gabriela LamasPathology Service, Hospital de Pediatría JP Garrahan, Buenos Aires 1245, Argentina.
Fabiana LubienieckiPathology Service, Hospital de Pediatría JP Garrahan, Buenos Aires 1245, Argentina.
Irene SzijanGenetic and Molecular Biology, University of Buenos Aires, Buenos Aires 1113, Argentina.
Jaume MoraDevelopmental Tumor Biology Laboratory, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.ORCID 0000-0001-5023-9819
Osvaldo PodhajcerNational Scientific and Technical Research Council, CONICET, Buenos Aires 1425, Argentina.
François DozUniversity of Paris and Institut Curie (SIREDO Center: Care, Innovation and Reserach in pediatric, Adolescent and Young Adults Oncology), CNRS, UMR144, Equipe Labellisée Ligue Contre le Cancer, 75005 Paris, France.ORCID 0000-0001-9286-4831
François RadvanyiUniversity of Paris and Institut Curie (SIREDO Center: Care, Innovation and Reserach in pediatric, Adolescent and Young Adults Oncology), CNRS, UMR144, Equipe Labellisée Ligue Contre le Cancer, 75005 Paris, France.
David H AbramsonOphthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-0118-6391
Andrea S LleraNational Scientific and Technical Research Council, CONICET, Buenos Aires 1425, Argentina.ORCID 0000-0002-0089-0061
Paula S SchaiquevichNational Scientific and Technical Research Council, CONICET, Buenos Aires 1425, Argentina.
Cinzia LavarinoDevelopmental Tumor Biology Laboratory, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
Guillermo L ChantadaNational Scientific and Technical Research Council, CONICET, Buenos Aires 1425, Argentina.ORCID 0000-0002-9375-9336
Garrahan Hospital · ARCentre National de la Recherche Scientifique · FRHospital Sant Joan de Déu Barcelona · ESFundación Instituto Leloir · ARMemorial Sloan Kettering Cancer Center · USInstitut de Recerca Sant Joan de DéuUniversidad de Buenos Aires · AR

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Agencia Nacional de Promoción Científica y Tecnológica PIDC 2014-0043Fondation Nelia et Amadeo Barletta Fund for metastatic retinoblastoma (2019-2021)Fundación Garrahan Subsidio de la Fundación Garrahan para el estudio del retinoblastoma de alto riesgo (2018-2020)Fundación Leo Messi Fund for children with cancerFundación Natalie Dafne Flexer de Ayuda al Niño con Cancer Aid for investigation and research in Paediatric OncologyFund for Ophthalmic Knowledge Fund for Ophthalmic knowledge 2019-2020Instituto Nacional del Cancer Protocolo GALOP 2 para el tratamiento del retinoblastomaInstituto Oncologico Henry Moore Grant for oncology researchNCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Most reports about copy number alterations (CNA) in retinoblastoma relate to patients with intraocular disease and features of children with extraocular relapse remain unknown, so we aimed to describe the CNA in this population. We evaluated 23 patients and 27 specimens from 4 centers. Seventeen cases had extraocular relapse after initial enucleation and six cases after an initial preservation attempt. We performed an analysis of CNA and

Indexed as

BCOR mutationscopy number alterationextraocular retinoblastomagenomicmetastasis

Identifiers

PMID33567541
PMCPMC7915502
OpenAlexW3126797990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.