Evidence map›Paper›PMID 33567536›Full record

ArticleInternational journal of molecular sciences2021

A Novel Triplet-Primed PCR Assay to Detect the Full Range of Trinucleotide CAG Repeats in the Huntingtin Gene (

Alessandro De Luca, Annunziata Morella, Federica Consoli, Sergio Fanelli, Julie R Thibert, Sarah Statt, Gary J Latham, Ferdinando Squitieri

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Clinical Review of Juvenile Huntington's Disease.Journal of Huntington's disease · 2024
    Review
  6. Article
  7. Article
  8. A deep population reference panel of tandem repeat variation.bioRxiv : the preprint server for biology · 2023
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Alessandro De LucaMedical Genetics Division, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0002-4408-8062
Annunziata MorellaMedical Genetics Division, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Federica ConsoliMedical Genetics Division, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Sergio FanelliHuntington and Rare Diseases Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0001-5832-8381
Julie R ThibertAsuragen, Inc., Austin, TX 78744, USA.
Sarah StattAsuragen, Inc., Austin, TX 78744, USA.
Gary J LathamAsuragen, Inc., Austin, TX 78744, USA.ORCID 0000-0002-9263-3475
Ferdinando SquitieriHuntington and Rare Diseases Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0002-7397-1727
Casa Sollievo della Sofferenza · ITAsuragen (United States) · US

Funding

Ministero della Salute RF-2016-02364123
6 · The paper itself

Abstract

The expanded CAG repeat number in

Indexed as

Trinucleotide RepeatsCohort StudiesGenetic TestingHumansHuntingtin ProteinHuntington DiseasePolymerase Chain ReactionHTT protein, humanHuntingtin ProteinHTT-CAG repeatsHuntington diseasenovel diagnostic testTP-PCR

Identifiers

PMID33567536
PMCPMC7916029
OpenAlexW3128366266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.