Evidence map›Paper›PMID 33567500›Full record

ArticleInternational journal of molecular sciences2021

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of

Janusz Blasiak, Ali Koskela, Elzbieta Pawlowska, Mikko Liukkonen, Johanna Ruuth, Elisa Toropainen, Juha M T Hyttinen, Johanna Viiri, John E Eriksson, Heping Xu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

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  15. Immune Cells in Subretinal Wound Healing and Fibrosis.Frontiers in cellular neuroscience · 2022
    Review
  16. Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration.International journal of molecular sciences · 2021
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Janusz BlasiakDepartment of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.ORCID 0000-0001-9539-9584
Ali KoskelaDepartment of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.
Elzbieta PawlowskaDepartment of Orthodontics, Medical University of Lodz, 92-217 Lodz, Poland.ORCID 0000-0002-5373-4783
Mikko LiukkonenDepartment of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.ORCID 0000-0002-4259-4041
Johanna RuuthDepartment of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.
Elisa ToropainenDepartment of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.
Juha M T HyttinenDepartment of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.
Johanna ViiriDepartment of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.
John E ErikssonTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
Heping XuThe Wellcome-Wolfson Institute of Experimental Medicine Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK.ORCID 0000-0003-4000-931X
Mei ChenThe Wellcome-Wolfson Institute of Experimental Medicine Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK.
Szabolcs FelszeghyInstitute of Biomedicine, University of Eastern Finland, Yliopistonranta 1 A, 70211 Kuopio, Finland.
Kai KaarnirantaDepartment of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.
University of Eastern Finland · FIQueen's University Belfast · GBÅbo Akademi University · FIMedical University of Lodz · PLUniversity of Łódź · PL

Funding

Health Research Council of the Academy of Finland 296840 and 333302Kuopion Yliopistollinen Sairaala 5503743National Science Centre Poland 2017/27/B/NZ3/00872
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is the most prevalent form of irreversible blindness worldwide in the elderly population. In our previous studies, we found that deficiencies in the nuclear factor, erythroid 2 like 2 (

Indexed as

Cellular SenescenceEpithelial-Mesenchymal TransitionOxidative StressAnimalsMacular DegenerationMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMitochondriaNF-E2-Related Factor 2Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhenotypeReactive Oxygen SpeciesRetinal Pigment EpitheliumSignal TransductionNfe2l2 protein, mouseNF-E2-Related Factor 2Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseReactive Oxygen Speciesage-related macular degenerationAMDepithelial-mesenchymal transitionNFE2L2/PGC-1α dKO micesenescence

Identifiers

PMID33567500
PMCPMC7915526
OpenAlexW3127494486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.