Evidence map›Paper›PMID 33567346›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2021

Arbiters of endogenous opioid analgesia: role of CNS estrogenic and glutamatergic systems.

Alan R Gintzler, Nai-Jiang Liu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alan R GintzlerDepartment of Obstetrics and Gynecology, State University of New York, Downstate Medical University, College of Medicine, Brooklyn, New York. Electronic address: alan.gintzler@downstate.edu.
Nai-Jiang LiuDepartment of Obstetrics and Gynecology, State University of New York, Downstate Medical University, College of Medicine, Brooklyn, New York.
SUNY Downstate Health Sciences University · US

Funding

Alternatives to prescription opioids: a precision medicine approach to harnessing endogenous opioids for pain relief and circumvention of prescription opioid abuseR01DA043774 · NIDA · SUNY DOWNSTATE MEDICAL CENTER · PI LIU, NAIJIANG, STEWART, MARK G · 2017 to 2021
$1.8M
NIDA NIH HHS R01 DA043774
6 · The paper itself

Abstract

Nociception and opioid antinociception in females are pliable processes, varying qualitatively and quantitatively over the reproductive cycle. Spinal estrogenic signaling via membrane estrogen receptors (mERs), in combination with multiple other signaling molecules [spinal dynorphin, kappa-opioid receptors (KOR), glutamate and metabotropic glutamate receptor 1 (mGluR

Indexed as

AnalgesiaAnalgesicsAnimalsCentral Nervous SystemChronic PainEstrogensFemaleGlutamatesHumansMaleModels, NeurologicalNociceptionOpioid PeptidesReceptors, EstrogenReceptors, GlutamateReceptors, OpioidAnalgesicsEstrogensGlutamatesOpioid PeptidesReceptors, EstrogenReceptors, GlutamateReceptors, Opioid

Identifiers

PMID33567346
PMCPMC8217383
OpenAlexW3127105078

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.