ArticleNeuron2021
Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Article
- Sleep lowers waking theta frequency in the rat hippocampus.Cell reports · 2026Article
- Neural and Navigational Features Influencing the Novelty Induced Benefits on Episodic Memory.Hippocampus · 2026Article
- Directional dynamics in the entorhinal cortex of male mice driven by behavioral constraints.Nature communications · 2026Article
- Distinct neural signatures of hippocampal population dynamics during locomotion-in-place.Scientific reports · 2026Article
- Emotional shaping of spatial encoding along the dorsal ventral axis of the hippocampus.Frontiers in systems neuroscience · 2026Review
- Hippocampal-Prelimbic Coupling During Context-Dependent Extinction Retrieval in Rats.Hippocampus · 2026Article
- Theta Activity Supports Landmark-Based Correction of Naturalistic Human Path Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Multisensory coding of self-motion and its contribution to navigation.Nature reviews. Neuroscience · 2025Review
- Spatial coding dysfunction and network instability in the aging medial entorhinal cortex.Nature communications · 2025Article
- Speed modulations in grid cell information geometry.Nature communications · 2025Article
- Neural Correlates of Flight Acceleration in Pigeons: Gamma-Band Activity and Local Functional Network Dynamics in the AId Region.Animals : an open access journal from MDPI · 2025Article
- Pedunculopontine-stimulation obstructs hippocampal theta rhythm and halts movement.Scientific reports · 2025Article
- Theta Oscillons in Behaving Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cell-type-specific contributions to theta-gamma coupled rhythms in the hippocampus.Network neuroscience (Cambridge, Mass.) · 2025Article
- Evidence of spatial periodic firing in the subiculum of mice.Frontiers in neural circuits · 2025Article
- Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry.Molecular brain · 2024Article
- Differences and similarities between human hippocampal low-frequency oscillations during navigation and mental simulation.bioRxiv : the preprint server for biology · 2024Article
- The medial entorhinal cortex encodes multisensory spatial information.Cell reports · 2024Article
- Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The theta rhythm organizes neural activity across hippocampus and entorhinal cortex. A role for theta oscillations in spatial navigation is supported by half a century of research reporting that theta frequency encodes running speed linearly so that displacement can be estimated through theta frequency integration. We show that this relationship is an artifact caused by the fact that the speed of freely moving animals could not be systematically disentangled from acceleration. Using an experimental procedure that clamps running speed at pre-set values, we find that the theta frequency of local field potentials and spike activity is linearly related to positive acceleration, but not negative acceleration or speed. The modulation by positive-only acceleration makes rhythmic activity at theta frequency unfit as a code to compute displacement or any other kinematic variable. Temporally precise variations in theta frequency may instead serve as a mechanism for speeding up entorhinal-hippocampal computations during accelerated movement.
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