Evidence map›Paper›PMID 33567075›Full record

ArticleThe Journal of clinical endocrinology and metabolism2021

Vertebral Fracture Assessment in Postmenopausal Women With Postsurgical Hypoparathyroidism.

Cristiana Cipriani, Salvatore Minisola, John P Bilezikian, Davide Diacinti, Luciano Colangelo, Valentina Piazzolla, Maurizio Angelozzi, Luciano Nieddu, Jessica Pepe, Daniele Diacinti

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Fracture risk in hypoparathyroidism: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Pooled it
  3. Palopegteriparatide for adults with chronic hypoparathyroidism: skeletal dynamics through 3 years of the phase 2 PaTH forward trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Trial
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  5. Observational
  6. Review
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  10. Increased risk of vertebral fractures and reduced risk of femur fractures in patients with chronic hypoparathyroidism: a nationwide cohort study in Sweden.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  11. Review
  12. Skeletal health status among patients with chronic hypoparathyroidism: results from the Canadian National Hypoparathyroidism Registry (CNHR).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
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  19. Article
  20. Fracture Risk in Patients with Hypoparathyroidism.Current osteoporosis reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Cristiana CiprianiDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
Salvatore MinisolaDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
John P BilezikianDivision of Endocrinology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Davide DiacintiDepartment of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Italy.
Luciano ColangeloDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
Valentina PiazzollaDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
Maurizio AngelozziDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
Luciano NiedduFaculty of Economics, UNINT University, Via Cristoforo Colombo, Rome, Italy.
Jessica PepeDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.
Daniele DiacintiDepartment of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Viale Regina Elena, Rome, Italy.
Policlinico Umberto I · ITUniversity of Rome Tor Vergata · ITColumbia University · USUniversità degli Studi Internazionali di Roma · IT

Funding

PRIMARY HYPERPARATHYROIDISMR01DK032333 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BILEZIKIAN, JOHN P · 1986 to 2018
$9.6M
NIDDK NIH HHS R01 DK032333
6 · The paper itself

Abstract

contextHypoparathyroidism is a rare endocrine disorder whose skeletal features include suppression of bone turnover and greater volume and width of the trabecular compartment. Few and inconsistent data are available on the prevalence of vertebral fractures (VF).

objectiveTo evaluate the prevalence of VF assessed by vertebral fracture assessment (VFA) in postmenopausal women with chronic postsurgical hypoparathyroidism.

designCross-sectional study.

settingAmbulatory referral center. PATIENTS OR OTHER

participantsFifty postmenopausal women (mean age 65.4 ± 9 years) with chronic postsurgical hypoparathyroidism and 40 age-matched healthy postmenopausal women (mean age 64.2 ± 8.6).

main outcome measuresLumbar spine, femoral neck, and total hip bone mineral density were measured by dual X-ray absorptiometry (Hologic Inc., USA) in all subjects. Site-matched spine trabecular bone score was calculated by TBS iNsight (Medimaps, Switzerland). Assessment of VF was made by VFA (iDXA, Lunar GE, USA) using the semiquantitative method and the algorithm-based qualitative assessment.

resultsAll-site BMD values were higher in the hypoparathyroid vs the control group. By VFA, we observed a 16% prevalence of VF in hypoparathyroid women vs 7.5% in control subjects. Among those with hypoparathyroidism who fractured, 5 (62.5%) had grade 1 wedge, 2 (25%) had grade 2 wedge, and 1 (12.5%) had grade 2 wedge and grade 2 biconcave VF. In the hypoparathyroid group, 57% with VFs and 32% without VFs had symptoms of hypoparathyroidism.

conclusionWe demonstrate for the first time that in postmenopausal women with chronic postsurgical hypoparathyroidism, VFs are demonstrable by VFA despite normal BMD.

Indexed as

Absorptiometry, PhotonAgedBone DensityChronic DiseaseCross-Sectional StudiesFemaleFemur NeckHumansHypoparathyroidismItalyLumbar VertebraeMiddle AgedOsteoporosis, PostmenopausalOsteoporotic FracturesParathyroidectomyPostmenopausefracturehypoparathyroidismpostmenopausal womenVFA

Identifiers

PMID33567075
PMCPMC8063231
OpenAlexW3126941935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.