ArticleClinics (Sao Paulo, Brazil)2021
Efficacy of autologous platelet-rich plasma gel in the treatment of refractory pressure injuries and its effect on wound healing time and patient quality of life.
Article in Clinics (Sao Paulo, Brazil), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Effect Evaluation of Platelet-Rich Plasma Combined with Vacuum Sealing Drainage on Serum Inflammatory Factors in Patients with Pressure Ulcer by Intelligent Algorithm-Based CT Image.Computational and mathematical methods in medicine · 2022Trial
- Step-by-Step Technique for Platelet-Rich Plasma Gel Preparation and Use in Knee Osteoarthritis.Arthroscopy techniques · 2026Article
- Efficacy of mesenchymal stem cells and platelet-rich plasma therapies on wound healing: A Systematic Review and meta-analysis.Regenerative therapy · 2025Review
- Platelet-Rich Plasma for Wound Healing in Diabetic Patients.Medicina (Kaunas, Lithuania) · 2025Review
- Autologous platelet rich gel in treatment of lower limb atherosclerotic occlusive disease in diabetic patients.World journal of diabetes · 2025Article
- The Effect of Platelet Rich Plasma on Wound Healing in Pressure Ulcer Patient Grade III and IV.International wound journal · 2025Article
- Platelet-rich plasma and plasma rich in growth factors in extra-oral wound care.Periodontology 2000 · 2025Review
- Applications of blood plasma derivatives for cutaneous wound healing: A mini-review of clinical studies.Regenerative therapy · 2024Review
- The Efficacy and Safety of Negative-Pressure Wound Therapy Combined With Platelet-Rich Plasma in Chronic Refractory Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Health science reports · 2024Review
- Green Synthesis of Zinc Oxide Nanoparticles fromInternational journal of nanomedicine · 2024Article
- The Benefits of Using Platelet-rich Plasma with Dermal Substitutes for Extremity Posttraumatic Skin Defects: A Short-term Outcome.Plastic and reconstructive surgery. Global open · 2024Article
- [Effect of nanofat combined with platelet-rich plasma for treatment of pressure injury wounds in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Negative pressure wound therapy for treating pressure ulcers.The Cochrane database of systematic reviews · 2023Review
- The efficacy and safety of platelet-rich plasma in the tendon-exposed wounds: a preliminary study.Journal of orthopaedic surgery and research · 2022Article
- Application Effect of Silver-Containing Dressings in the Repair of Chronic Refractory Wounds.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Closure of a Difficult-to-Manage Chronic Pressure Injury with the Use of Autologous Platelet-Rich Plasma (APRP).International medical case reports journal · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the efficacy of autologous platelet-rich plasma (PRP) gel in the treatment of refractory pressure injuries and its effect on wound healing time and quality of life of patients.
methodsA random number table method was used to group 102 patients with refractory pressure injuries into either a control group (CG) (51 cases) receiving negative pressure wound therapy (NPWT) or a study group (SG) (51 cases) receiving NPWT+PRP gel.
resultsThe total efficacy rate in the SG (92.16%) was higher than that in the CG (76.47%) (p<0.05). The SG exhibited lower visual analog scale (VAS) scores and pressure ulcer scale for healing (PUSH) scores, smaller wound sizes and depths, and shorter wound healing times than the CG after 21 days of treatment (p<0.05). After 6 months of treatment, the SG scored higher than the CG on the psychological, physiological, social functions, and daily activity domains on the World Health Organization Quality of Life (WHOQOL-BREF) scale (p<0.05). The incidence of postoperative complications in the SG (13.73%) was not significantly different from that of the CG (7.84%) (p>0.05).
conclusionIn the treatment of refractory pressure injuries, PRP gel can accelerate wound healing, reduce wound pain, shorten the treatment cycle, regulate tissue inhibitor matrix metalloproteinase-1 (TIMP-1) and matrix metalloproteinase-9 (MMP-9) levels and the expression of specific proteins in granulation tissue, reduce the levels of the inflammatory factors interleukin-1β (IL-1β), IL-8, and tumor necrosis factor-α (TNF-α), and improve the quality of life of patients without increasing complications.
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