ArticlePloS one2021
Neuron-specific enolase level as a predictor of neurological outcome in near-hanging patients: A retrospective multicenter study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Role of serum neuron-specific enolase levels in the early diagnosis and prognosis of sepsis-associated encephalopathy: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- The potential impact of clindamycin on neurosurgery patients: a randomized controlled trial.Inflammopharmacology · 2025Trial
- Complete Neurological Recovery Following Suicidal Near-Hanging: A Case Report From Ethiopia.Clinical medicine insights. Case reports · 2026Article
- Neurological Damage Measured by S-100b and Neuron-Specific Enolase in Patients Treated with Electroconvulsive Therapy.Brain sciences · 2024Article
- Plasma neurological biomarkers as a measure of neurotoxicity in pediatric dental general anesthesia: a prospective observational feasibility study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Observational
- Characterizing neuroinvasion and neuropathology of SARS-CoV-2 by using AC70 human ACE2 transgenic mice.Frontiers in microbiology · 2024Article
- Plasma biomarkers for brain injury in extracorporeal membrane oxygenation.Acute and critical care · 2023Article
- Article
- Plasma Neuron-Specific Enolase is not a reliable biomarker for staging Trypanosoma brucei rhodesiense sleeping sickness patients.BMC research notes · 2022Article
- 4-Hydroxyphenyllactic Acid in Cerebrospinal Fluid as a Possible Marker of Post-Neurosurgical Meningitis: Retrospective Study.Journal of personalized medicine · 2022Article
- Musculoskeletal, airway, and vascular injuries in the patient with nonjudicial hanging: A narrative review for the emergency clinician.Turkish journal of emergency medicineReview
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNeuron-specific enolase (NSE) is frequently used to predict neurological outcomes in patients with hypoxic brain injury. Hanging can cause hypoxic brain damage, and survivors can suffer from neurological deficits that may impair daily activities. Here, we investigated the utility of the initial serum NSE level as a predictor of neurological outcomes in near-hanging patients with decreased consciousness.
methodsThis retrospective multicenter study was conducted in patients who visited the emergency department due to near-hanging injury from October 2013 to February 2019 at three university hospitals in Korea. They were divided into two groups according to the presence of out-of-hospital cardiac arrest. The neurological outcome was determined using the Cerebral Performance Category (CPC) measured at the time of discharge. Multivariate analysis was performed to determine whether initial serum NSE is an independent predictor of neurological outcome.
resultsOf the 70 patients included in the study, 44 showed a poor neurological outcome (CPC score = 3-5). Among the 52 patients with cardiac arrest, only 10 (19.2%) were discharged with good neurological outcome (CPC score = 1-2). In the whole cohort, a high serum NSE level was a significant predictor of poor neurological outcome (odds ratio [OR], 1.343; 95% confidence interval [CI], 1.003-1.800, p = 0.048). Among the patients with cardiac arrest, a high serum NSE level was a significant predictor of poor neurological outcome (OR, 1.138; 95% CI, 1.009-1.284, p = 0.036).
conclusionsIn near-hanging patients, a high initial serum NSE level is an independent predictor of poor neurological outcome.
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