ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2021
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In one paragraph
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
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- Comprehensive analysis of immune-related genes associated with the microenvironment of patients with unexplained infertility.Annals of translational medicine · 2023Article
- Case Report: Chronic inflammatory demyelinating polyradiculoneuropathy rather than hemophagocytic lymphohistiocytosis-the initial phenotype of PRF1 gene mutation.Frontiers in immunology · 2023Article
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- Natural Killer Cells in Multiple Sclerosis: Entering the Stage.Frontiers in immunology · 2022Review
- Single-cell transcriptomics reveals cell type-specific immune regulation associated with anti-NMDA receptor encephalitis in humans.Frontiers in immunology · 2022Article
- Infections and Multiple Sclerosis: From the World to Sardinia, From Sardinia to the World.Frontiers in immunology · 2021Review
- Identification of Hub Genes in Tuberculosis via Bioinformatics Analysis.Computational and mathematical methods in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
50 authors at 12 institutions in 4 countries.
Carlo SidoreIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Valeria OrrùIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Eleonora CoccoDepartment of Medical Sciences and Public health, Multiple Sclerosis Centre, University of Cagliari, Cagliari, Italy.ORCID 0000-0002-3878-8820
Maristella SteriIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Jamie Rj InshawJDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Oxford, UK/Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, Oxford, UK.
Maristella PitzalisIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Antonella MulasIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Stuart McGurnaghanDiabetes Medical Informatics and Epidemiology, The University of Edinburgh, Edinburgh, Scotland.
Jessica FrauDepartment of Medical Sciences and Public health, Multiple Sclerosis Centre, University of Cagliari, Cagliari, Italy.
Eleonora PorcuCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland/Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Fabio BusoneroIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Mariano DeiIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Sandra LaiIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Gabriella SoleIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Francesca VirdisIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Valentina SerraIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Fausto PoddieDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Alessandro DelitalaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy/Department of Surgical, Medical and Experimental Sciences, University of Sassari, Sassari, Italy.
Michele MarongiuIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Francesca DeiddaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Mauro PalaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.ORCID 0000-0002-3165-5291
Matteo FlorisDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.ORCID 0000-0003-4385-9336
Marco MasalaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.ORCID 0000-0001-5556-9964
Suna Onengut-GumuscuCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-6563-8334
Catherine C RobertsonCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Lidia LeoniCenter for Advanced Studies, Research and Development in Sardinia (CRS4), Parco Scientifico e Tecnologico della Sardegna, Pula, Italy.
Annapaola FrongiaUnit of Paediatric Diabetes, Brotzu Hospital, Cagliari, Italy.
Maria Rossella RicciardiDiabetologia Pediatrica, Azienda Ospedaliera G. Brotzu, Cagliari, Italy.
Margherita ChessaStruttura Complessa di Pediatria, Azienda Ospedaliera G. Brotzu, Cagliari, Italy.
Nazario OllaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Mario LovicuIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Annalisa LoizeddaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Andrea MaschioIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Luisa MereuUnità Operativa di Pediatria, Ospedale San Martino di Oristano, Oristano, Italy.
Paola FerrignoReparto di Neurologia, Azienda Ospedaliera G. Brotzu, Cagliari, Italy.
Nicolo CurreliIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Lenuta BalaciIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Francesco LoiIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Liana Ap FerreliIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Maria Grazia PiliaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Antonello PaniIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy/Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliera G. Brotzu, Cagliari, Italy.
Maria Giovanna MarrosuDepartment of Medical Sciences and Public health, Multiple Sclerosis Centre, University of Cagliari, Cagliari, Italy.
Goncalo R AbecasisCenter for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Helen ColhounDiabetes Medical Informatics and Epidemiology, The University of Edinburgh, Edinburgh, Scotland.
John A ToddJDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Oxford, UK/Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, Oxford, UK.
David SchlessingerLaboratory of Genetics and Genomics, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA.
Edoardo FiorilloIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy/Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Magdalena ZoledziewskaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.ORCID 0000-0002-3033-6133
Institute of Genetic and Biomedical Research · ITAzienda Ospedaliera G. Brotzu · ITUniversity of Sassari · ITUniversity of Cagliari · ITUniversity of Virginia · USCentre for Human Genetics · GBUniversity of Edinburgh · GBCenter for Advanced Studies Research and Development in Sardinia · ITFondazione Centro Marino Internazionale · ITNational Institutes of Health · USSIB Swiss Institute of Bioinformatics · CHUniversity of Michigan · US
Funding
GENETICS & EPIDEMIOLOGY OF AGAING - ASSOCIATED CONDITIONS IN THE SARDINIAN POPULN01AG12109 · NIA · CONSIGLIO NAZIONALE DELLE RICERCHE · PI UDA, MANUELA · 2007 to 2011
$7.8MAging-related Traits and Disease Risk Factors in a Sardinian Population CohortZIAAG000675 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM · 2009 to 2021
$5.7MDepartment of HealthNIA NIH HHS N01AG12109NIDA NIH HHS HHSN271201100005CWellcome Trust 076113Wellcome Trust 091157Wellcome Trust 107212
Abstract
backgroundDefective alleles within the
objectiveThe aim of this study was to determine the function of hypomorph
methodsWe cross-compare the association data for
resultsWe report that
conclusionOur results indicate opposing contributions of the cytotoxic T-cell compartment to MS and T1D pathogenesis.
Indexed as
AutoimmunityImmune SystemChildHumansInflammationLIM-Homeodomain ProteinsMuscle ProteinsMutationPerforinTranscription FactorsFHL2 protein, humanLIM-Homeodomain ProteinsMuscle ProteinsPerforinPRF1 protein, humanTranscription Factorscytokine stormcytotoxic lymphocyteshemophagocytic lymphohistiocytosisinflammationmultiple sclerosisPerforintype 1 diabetes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.