Evidence map›Paper›PMID 33566572›Full record

ArticleACS applied materials & interfaces2021

Nano-optoelectrodes Integrated with Flexible Multifunctional Fiber Probes by High-Throughput Scalable Fabrication.

Shan Jiang, Junyeob Song, Yujing Zhang, Meitong Nie, Jongwoon Kim, Ana Lopez Marcano, Kelly Kadlec, William A Mills, Xiaodong Yan, Hefei Liu and 6 more

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Opportunities and Challenges of Brain-on-a-Chip Interfaces.Cyborg and bionic systems (Washington, D.C.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Shan JiangBradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, Virginia 24060, United States.ORCID http://orcid.org/0000-0002-1567-2745
Junyeob SongBradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, Virginia 24060, United States.ORCID http://orcid.org/0000-0001-6369-823X
Yujing ZhangBradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, Virginia 24060, United States.
Meitong NieBradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, Virginia 24060, United States.
Jongwoon KimBradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, Virginia 24060, United States.
Ana Lopez MarcanoBradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, Virginia 24060, United States.
Kelly KadlecBradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, Virginia 24060, United States.
William A MillsTranslational Biology, Medicine, and Health, Virginia Tech, Roanoke, Virginia 24016, United States.
Xiaodong YanMing Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, California 90089, United States.
Hefei LiuMing Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, California 90089, United States.ORCID http://orcid.org/0000-0001-6533-7112
Rong TongDepartment of Chemical Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID http://orcid.org/0000-0002-2034-9272
Han WangFralin Biomedical Research Institute, Roanoke, Virginia 24016, United States.ORCID http://orcid.org/0000-0001-5121-3362
Ian F KimbroughSchool of Neuroscience, Virginia Tech, Blacksburg, Virginia 24061, United States.
Harald SontheimerTranslational Biology, Medicine, and Health, Virginia Tech, Roanoke, Virginia 24016, United States.
Wei ZhouBradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, Virginia 24060, United States.ORCID http://orcid.org/0000-0002-5257-3885
Xiaoting JiaBradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, Virginia 24060, United States.ORCID http://orcid.org/0000-0003-4890-6103
Virginia Tech · USBiomedical Research Institute · USUniversity of Southern California · US

Funding

The Role of Ion Transport in Glioma Migration, Proliferation, and ApoptosisR01NS036692 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SONTHEIMER, HARALD W · 1997 to 2024
$6.8M
Amino Acid Transport and the Biology of Human GliomasR01NS052634 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SONTHEIMER, HARALD W · 2005 to 2015
$3.7M
3D multifunctional deep brain interface for seizure detection and interventionR01NS123069 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI JIA, XIAOTING, SONTHEIMER, HARALD W · 2021 to 2025
$1.9M
Glioma-Astrocyte Vascular InteractionsR01NS082851 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SONTHEIMER, HARALD W · 2013 to 2016
$1.3M
NINDS NIH HHS R01 NS036692NINDS NIH HHS R01 NS052634NINDS NIH HHS R01 NS082851NINDS NIH HHS R01 NS123069
6 · The paper itself

Abstract

Metallic nano-optoelectrode arrays can simultaneously serve as nanoelectrodes to increase the electrochemical surface-to-volume ratio for high-performance electrical recording and optical nanoantennas to achieve nanoscale light concentrations for ultrasensitive optical sensing. However, it remains a challenge to integrate nano-optoelectrodes with a miniaturized multifunctional probing system for combined electrical recording and optical biosensing in vivo. Here, we report that flexible nano-optoelectrode-integrated multifunctional fiber probes can have hybrid optical-electrical sensing multimodalities, including optical refractive index sensing, surface-enhanced Raman spectroscopy, and electrophysiological recording. By physical vapor deposition of thin metal films through free-standing masks of nanohole arrays, we exploit a scalable nanofabrication process to create nano-optoelectrode arrays on the tips of flexible multifunctional fiber probes. We envision that the development of flexible nano-optoelectrode-integrated multifunctional fiber probes can open significant opportunities by allowing for multimodal monitoring of brain activities with combined capabilities for simultaneous electrical neural recording and optical biochemical sensing at the single-cell level.

Indexed as

Biosensing TechniquesOptical FibersAnimalsBiocompatible MaterialsElectrodesMaleMiceMice, Inbred C57BLNanoparticlesParticle SizeRefractometrySpectrum Analysis, RamanSurface PropertiesTemperatureBiocompatible Materialsconvergence fiber drawingin vivo neural recordingmultifunctional fiber-based neural probenano-optoelectrodesnanoplasmonic sensing

Identifiers

PMID33566572
PMCPMC10564641
OpenAlexW3126330603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.