ArticleHuman brain mapping2021
Structural control energy of resting-state functional brain states reveals less cost-effective brain dynamics in psychosis vulnerability.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Optimizing brain functional-structural architecture with cTBS to reduce relapse in alcohol use disorder: a randomized controlled trial.Molecular psychiatry · 2026Article
- Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity.Nature communications · 2026Article
- Brain energetic landscapes shape state dysregulation in major depressive disorder: a morphological network controllability perspective.Translational psychiatry · 2026Article
- The Neural Association Between Symptom and Cognition in Major Depressive Disorder: A Network Control Theory Study.Human brain mapping · 2025Article
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
- Transient brain activity dynamics discriminate levels of consciousness during anesthesia.Communications biology · 2024Article
- Development of the brain network control theory and its implications.Psychoradiology · 2024Review
- A framework for optimal control of oscillations and synchrony applied to non-linear models of neural population dynamics.Frontiers in computational neuroscience · 2024Article
- Controlling target brain regions by optimal selection of input nodes.PLoS computational biology · 2024Article
- The confound of hemodynamic response function variability in human resting-state functional MRI studies.Frontiers in neuroscience · 2023Article
- A pattern of cognitive resource disruptions in childhood psychopathology.Network neuroscience (Cambridge, Mass.) · 2023Article
- Uncovering the biological basis of control energy: Structural and metabolic correlates of energy inefficiency in temporal lobe epilepsy.Science advances · 2022Article
- Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson's disease.Communications biology · 2022Article
- Alterations in white matter network dynamics in patients with schizophrenia and bipolar disorder.Human brain mapping · 2022Article
- Altered functional brain dynamics in chromosome 22q11.2 deletion syndrome during facial affect processing.Molecular psychiatry · 2022Article
- Structure-function models of temporal, spatial, and spectral characteristics of non-invasive whole brain functional imaging.Frontiers in neuroscience · 2022Review
- Abnormal nodal and global network organization in resting state functional MRI from subjects with the 22q11 deletion syndrome.Scientific reports · 2021Article
- Structural control energy of resting-state functional brain states reveals less cost-effective brain dynamics in psychosis vulnerability.Human brain mapping · 2021Article
- The missing role of gray matter in studying brain controllability.Network neuroscience (Cambridge, Mass.) · 2021Article
- A practical guide to methodological considerations in the controllability of structural brain networks.Journal of neural engineering · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
How the brain's white-matter anatomy constrains brain activity is an open question that might give insights into the mechanisms that underlie mental disorders such as schizophrenia. Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental disorder with an extremely high risk for psychosis providing a test case to study developmental aspects of schizophrenia. In this study, we used principles from network control theory to probe the implications of aberrant structural connectivity for the brain's functional dynamics in 22q11DS. We retrieved brain states from resting-state functional magnetic resonance images of 78 patients with 22q11DS and 85 healthy controls. Then, we compared them in terms of persistence control energy; that is, the control energy that would be required to persist in each of these states based on individual structural connectivity and a dynamic model. Persistence control energy was altered in a broad pattern of brain states including both energetically more demanding and less demanding brain states in 22q11DS. Further, we found a negative relationship between persistence control energy and resting-state activation time, which suggests that the brain reduces energy by spending less time in energetically demanding brain states. In patients with 22q11DS, this behavior was less pronounced, suggesting a deficiency in the ability to reduce energy through brain activation. In summary, our results provide initial insights into the functional implications of altered structural connectivity in 22q11DS, which might improve our understanding of the mechanisms underlying the disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.