Evidence map›Paper›PMID 33566386›Full record

ArticleThe Journal of physiology2022

Lactate in contemporary biology: a phoenix risen.

George A Brooks, Jose A Arevalo, Adam D Osmond, Robert G Leija, Casey C Curl, Ashley P Tovar

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 3 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 3 syntheses or guidelines pooled it, 208 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Cardiovascular effects of lactate in healthy adults.Critical care (London, England) · 2025
    Trial
  6. Trial
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  14. Review
  15. Review
  16. bioRxiv : the preprint server for biology · 2026
    Article
  17. Brain-muscle axis regulation of neuroinflammation and sarcopenia in Parkinson's disease: the bridging role of lactylation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  18. Review
  19. Article
  20. Review

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

George A BrooksExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, USA.ORCID 0000-0002-1389-1629
Jose A ArevaloExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, USA.
Adam D OsmondExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, USA.
Robert G LeijaExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, USA.
Casey C CurlExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, USA.
Ashley P TovarExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, USA.
University of California, Berkeley · US

Funding

Aging Mitochondrial Fragmentation and Metabolic InflexibilityR01AG059715 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI BROOKS, GEORGE AUSTIN · 2018 to 2022
$3.0M
NIA NIH HHS R01 AG059715
6 · The paper itself

Abstract

After a century, it's time to turn the page on understanding of lactate metabolism and appreciate that lactate shuttling is an important component of intermediary metabolism in vivo. Cell-cell and intracellular lactate shuttles fulfil purposes of energy substrate production and distribution, as well as cell signalling under fully aerobic conditions. Recognition of lactate shuttling came first in studies of physical exercise where the roles of driver (producer) and recipient (consumer) cells and tissues were obvious. Moreover, the presence of lactate shuttling as part of postprandial glucose disposal and satiety signalling has been recognized. Mitochondrial respiration creates the physiological sink for lactate disposal in vivo. Repeated lactate exposure from regular exercise results in adaptive processes such as mitochondrial biogenesis and other healthful circulatory and neurological characteristics such as improved physical work capacity, metabolic flexibility, learning, and memory. The importance of lactate and lactate shuttling in healthful living is further emphasized when lactate signalling and shuttling are dysregulated as occurs in particular illnesses and injuries. Like a phoenix, lactate has risen to major importance in 21st century biology.

Indexed as

GlycolysisLactic AcidBiologyExerciseMitochondriaLactic Acidexercisefibre typegene adaptationgluconeogenesisglycogenolysisindirect pathwaylactate shuttlelactate signallingmicrobiomemusclepostabsorptive metabolismpostprandial metabolismsatiety

Identifiers

PMID33566386
PMCPMC9188361
OpenAlexW3127360834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.