Evidence map›Paper›PMID 33566185›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2021

Pacemaker lead-associated tricuspid regurgitation in patients with or without pre-existing right ventricular dilatation.

Martin Riesenhuber, Andreas Spannbauer, Marianne Gwechenberger, Thomas Pezawas, Christoph Schukro, Günter Stix, Matthias Schneider, Georg Goliasch, Anahit Anvari, Thomas Wrba and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Evolution and prognosis of tricuspid and mitral regurgitation following cardiac implantable electronic devices: a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Pooled it
  2. Impact of stylet-driven lead for left bundle branch area pacing on tricuspid valve function: A comparative analysis with conventional CRT.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  3. Article
  4. Article
  5. [Research of tricuspid regurgitation associated with cardiac implantable electronic devices].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  6. Review
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  8. Tricuspid Regurgitation in the Setting of Cardiac Implantable Electronic Devices.Structural heart : the journal of the Heart Team · 2025
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  18. Valvular Heart Disease Epidemiology.Medical sciences (Basel, Switzerland) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Martin RiesenhuberDepartment of Cardiology, Medical University of Vienna, Vienna, Austria.
Andreas SpannbauerDepartment of Cardiology, Medical University of Vienna, Vienna, Austria.
Marianne GwechenbergerDepartment of Cardiology, Medical University of Vienna, Vienna, Austria.
Thomas PezawasDepartment of Cardiology, Medical University of Vienna, Vienna, Austria.
Christoph SchukroDepartment of Cardiology, Medical University of Vienna, Vienna, Austria.
Günter StixDepartment of Cardiology, Medical University of Vienna, Vienna, Austria.
Matthias SchneiderDepartment of Cardiology, Medical University of Vienna, Vienna, Austria.
Georg GoliaschDepartment of Cardiology, Medical University of Vienna, Vienna, Austria.
Anahit AnvariDepartment of Cardiology, Medical University of Vienna, Vienna, Austria.
Thomas WrbaMedical University of Vienna, IT Systems and Communications, Vienna, Austria.
Cesar KhazenDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Martin AndreasDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Günther LauferDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Christian HengstenbergDepartment of Cardiology, Medical University of Vienna, Vienna, Austria.
Mariann GyongyosiDepartment of Cardiology, Medical University of Vienna, Vienna, Austria. mariann.gyongyosi@meduniwien.ac.at.
Medical University of Vienna · AT

Funding

H2020 Future and Emerging Technologies 732170
6 · The paper itself

Abstract

backgroundTranscatheter tricuspid valve intervention became an option for pacemaker lead-associated tricuspid regurgitation. This study investigated the progression of tricuspid regurgitation (TR) in patients with or without pre-existing right ventricular dilatation (RVD) undergoing pacemaker implantation.

methodsPatients were included if they had implantation of transtricuspid pacemaker lead and completed echocardiography before and after implantation. The cohort was divided in patients with and without RVD (cut-off basal RV diameter ≥ 42 mm). TR was graded in none/mild, moderate, and severe. Worsening of one grade was defined as progression. Survival analyses were plotted for 10 years.

resultsIn total, 990 patients were analyzed (24.5% with RVD). Progression of TR occurred in 46.1% of patients with RVD and in 25.6% of patients without RVD (P < 0.001). Predictors for TR progression were RV dilatation (OR 2.04; 95% CI 1.27-3.29; P = 0.003), pre-existing TR (OR 4.30; 95% CI 2.51-7.38; P < 0.001), female sex (OR 1.68; 95% CI 1.16-2.43; P = 0.006), single RV lead (OR 1.67; 95% CI 1.09-2.56; P = 0.018), mitral regurgitation (OR 2.08; 95% CI 1.42-3.05; P < 0.001), and enlarged left atrium (OR 1.98; 95% CI 1.07-3.67; P = 0.03). Survival-predictors were pacemaker lead-associated TR (HR 1.38; 95% CI 1.04-1.84; P = 0.028), mitral regurgitation (HR 1.34; 95% CI 1.02-1.77; P = 0.034), heart failure (HR 1.75; 95% CI 1.31-2.33; P < 0.001), kidney disease (HR 1.62; 95% CI 1.25-2.11; P < 0.001), and age ≥ 80 years (HR 2.84; 95% CI 2.17-3.71; P < 0.001).

conclusionsPatients with RVD receiving pacemaker suffered from increased TR progression, leading to decreased survival.

Indexed as

AgedCardiomyopathy, DilatedEchocardiographyEquipment FailureFemaleFollow-Up StudiesHumansMalePacemaker, ArtificialPrognosisRetrospective StudiesTricuspid ValveTricuspid Valve InsufficiencyVentricular Dysfunction, RightDevice complicationsPacemakerRight ventricleTricuspid regurgitationValvular heart disease

Identifiers

PMID33566185
PMCPMC8166708
OpenAlexW3128463312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.