Trial reportIntensive care medicine2021
Early and sustained Lactobacillus plantarum probiotic therapy in critical illness: the randomised, placebo-controlled, restoration of gut microflora in critical illness trial (ROCIT).
Trial report in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- The Health Benefits of Probiotic Lactiplantibacillus plantarum: A Systematic Review and Meta-Analysis.Probiotics and antimicrobial proteins · 2025Pooled it
- Strategies to Maximize the Benefits of Evidence-Based Enteral Nutrition: A Narrative Review.Nutrients · 2025Pooled it
- Role of probiotic supplementation in preventing ventilator-associated pneumonia among critically ill patients-a critical umbrella review of meta-analyses of randomized controlled trials.Frontiers in nutrition · 2025Pooled it
- The role of probiotics in nutritional intake and clinical outcomes of critically Ill children with severe sepsis: a double-blind, placebo-controlled trial.Scientific reports · 2026Trial
- The Role of the Respiratory Microbiome in Pneumonia.Clinics in chest medicine · 2026Review
- Sortase A regulates cell wall integrity, quorum sensing, and biofilm formation to modulate adhesion properties inApplied and environmental microbiology · 2026Article
- Narrative review on microbiota and sepsis: the host's betrayal?Internal and emergency medicine · 2026Review
- Gut microbiota and sepsis: mechanisms, clinical correlations, and therapeutic prospects.Frontiers in medicine · 2026Article
- The immunology of sepsis: translating new insights into clinical practice.Nature reviews. Nephrology · 2026Review
- Article
- The gastrointestinal microbiome in critical illness: A Clinician's guide to mechanisms, emerging tools, and therapeutic questions.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Review
- Probiotics: A Little Help for Enteral Nutritional Therapy in Critically Ill Adults.International journal of molecular sciences · 2025Review
- NMR Spectroscopy-Based Lipoprotein and Glycoprotein Biomarkers Differentiate Acute and Chronic Inflammation in Diverse Healthy and Disease Population Cohorts.Journal of proteome research · 2025Article
- Fecal metabolite profiling identifies critically ill patients with increased 30-day mortality.Science advances · 2025Article
- Probiotic treatment in an intensive care unit: a narrative review.Journal of intensive care · 2025Review
- Strain-Specific Therapeutic Potential ofNutrients · 2025Article
- The Japanese Critical Care Nutrition Guideline 2024.Journal of intensive care · 2025Review
- Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition.Nature communications · 2025Article
- Effects of probiotic treatment on the prognosis of patients with sepsis: a systematic review.World journal of emergency medicine · 2025Review
- Stratification of Sepsis Patients on Admission into the Intensive Care Unit According to Differential Plasma Metabolic Phenotypes.Journal of proteome research · 2024Article
Corrections and comments
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Authors and funding
25 authors at 9 institutions in 2 countries.
Funding
Abstract
purposeIn adults requiring treatment in an intensive care unit, probiotic therapy using Lactobacillus plantarum 299v may reduce nosocomial infection. The aim of this study was to determine whether early and sustained L. plantarum 299v therapy administered to adult ICU patients increased days alive and at home.
methodsA multicentre, parallel group, placebo-controlled, randomised clinical trial was conducted. Adult patients within 48 h of intensive care admission and expected to require intensive care beyond the day after recruitment were eligible to participate. L plantarum 299v or placebo were administered immediately after enrolment and continued for 60 days. The primary outcome was days alive and out of hospital to Day 60 (DAOH
resultsThe median [interquartile range (IQR)] number of DAOH
conclusionEarly and sustained untargeted administration of probiotic therapy with Lactobacillus plantarum 299v to adult patients admitted to the ICU is safe, but not associated with improved patient outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.