Evidence map›Paper›PMID 33566014›Full record

ArticleJournal of synchrotron radiation2020

X-ray phase contrast tomography for the investigation of amyotrophic lateral sclerosis.

Ginevra Begani Provinciali, Nicola Pieroni, Inna Bukreeva, Michela Fratini, Lorenzo Massimi, Laura Maugeri, Francesca Palermo, Fabrizio Bardelli, Alberto Mittone, Alberto Bravin and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of synchrotron radiation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Ginevra Begani ProvincialiPhysics Department `Sapienza' University, CNR-Institute of Nanotechnology, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Nicola PieroniPhysics Department `Sapienza' University, CNR-Institute of Nanotechnology, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Inna BukreevaPhysics Department `Sapienza' University, CNR-Institute of Nanotechnology, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Michela FratiniPhysics Department `Sapienza' University, CNR-Institute of Nanotechnology, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Lorenzo MassimiDepartment of Medical Physics and Biomedical Engineering, University College London, Gower Street, London WC1E 6BT, United Kingdom.
Laura MaugeriFondazione Santa Lucia IRCCS, Via Ardeatina 306, 00179 Rome, Italy.
Francesca PalermoPhysics Department `Sapienza' University, CNR-Institute of Nanotechnology, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Fabrizio BardelliPhysics Department `Sapienza' University, CNR-Institute of Nanotechnology, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Alberto MittoneEuropean Synchrotron Radiation Facility, 71 Avenue des Martyrs, 38043 Grenoble, France.ORCID 0000-0002-2018-5714
Alberto BravinEuropean Synchrotron Radiation Facility, 71 Avenue des Martyrs, 38043 Grenoble, France.
Giuseppe GigliCNR Nanotec, Institute of Nanotechnology, via Monteroni, 73100 Lecce, Italy.
Francesco GentileNeuropathology Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.
Andrea FossaghiNeuropathology Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.
Nilo RivaNeuropathology Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.
Angelo QuattriniNeuropathology Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.
Alessia CedolaPhysics Department `Sapienza' University, CNR-Institute of Nanotechnology, Piazzale Aldo Moro 5, 00185 Rome, Italy.
San Raffaele University of Rome · ITEuropean Synchrotron Radiation Facility · FRFondazione Santa Lucia · ITParisTech · FRUniversity College London · GBUniversity of Calabria · ITUniversity of Salento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting motor neurons. Pre-clinical studies drive the development of animal models that well mimic ALS disorder and enable both the dissection of disease processes and an early assessment of therapy efficacy. A comprehensive knowledge of neuronal and vascular lesions in the brain and spinal cord is an essential factor to understand the development of the disease. Spatial resolution and bidimensional imaging are important drawbacks limiting current neuroimaging tools, while neuropathology relies on protocols that may alter tissue chemistry and structure. In contrast, recent ex vivo studies in mice demonstrated that X-ray phase-contrast tomography enables study of the 3D distribution of both vasculature and neuronal networks, without sample sectioning or use of staining. Here we present our findings on ex vivo SOD1

Indexed as

Amyotrophic Lateral SclerosisAnimalsDisease Models, AnimalImaging, Three-DimensionalMiceMice, TransgenicSensitivity and SpecificitySignal-To-Noise RatioSpinal CordTomography, X-Ray ComputedALSspinal cordX-ray phase contrast tomography

Identifiers

PMID33566014
PMCPMC7336179
OpenAlexW3034832944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.