Evidence map›Paper›PMID 33565718›Full record

ArticleFEBS open bio2021

Lysine 268 adjacent to transmembrane helix 5 of hamster P-glycoprotein is the major photobinding site of iodomycin in CHO B30 cells.

Annette Demmer, Hubert Thole, Manfred Raida, Burkhard Tümmler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Annette DemmerKlinische Forschergruppe, Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie, Medizinische Hochschule Hannover, Germany.
Hubert TholeKlinische Forschergruppe, Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie, Medizinische Hochschule Hannover, Germany.
Manfred RaidaSingapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore.
Burkhard TümmlerKlinische Forschergruppe, Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie, Medizinische Hochschule Hannover, Germany.ORCID 0000-0002-2566-8758
Medizinische Hochschule Hannover · DENational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

P-glycoprotein (Pgp) detoxifies cells by exporting hundreds of chemically dissimilar hydrophobic and amphipathic compounds and is implicated in multidrug resistance (MDR) in the treatment of cancers. Photoaffinity labeling of plasma membrane vesicles of MDR CHO B30 cells with the anthracycline [

Indexed as

Binding SitesProtein ConformationProtein Interaction Domains and MotifsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1CHO CellsCricetinaeCricetulusDaunorubicinHumansIodine RadioisotopesLysineMembrane GlycoproteinsPeptidesProtein BindingStructure-Activity RelationshipATP Binding Cassette Transporter, Subfamily B, Member 1DaunorubicinIodine-125Iodine RadioisotopesiodomycinLysineMembrane GlycoproteinsPeptidesABC transporteranthracyclinedrug-binding siteEdman sequencingmultidrug resistanceP-glycoprotein

Identifiers

PMID33565718
PMCPMC8016128
OpenAlexW3127134282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.