Evidence map›Paper›PMID 33565711›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

Safety and immunogenicity of adjuvanted recombinant subunit herpes zoster vaccine in lung transplant recipients.

Cedric Hirzel, Arnaud G L'Huillier, Victor H Ferreira, Tina Marinelli, Terrance Ku, Matthew Ierullo, Congrong Miao, D Scott Schmid, Stephen Juvet, Atul Humar and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Assessing and restoring adaptive immunity to HSV, VZV, and HHV-6 in solid organ and hematopoietic cell transplant recipients.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Review
  8. Article
  9. Humoral and cellular immune response and safety of two-dose SARS-CoV-2 mRNA-1273 vaccine in solid organ transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Cedric HirzelTransplant Infectious Diseases and Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-7870-912X
Arnaud G L'HuillierTransplant Infectious Diseases and Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.ORCID 0000-0001-9230-7285
Victor H FerreiraTransplant Infectious Diseases and Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.
Tina MarinelliTransplant Infectious Diseases and Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.
Terrance KuTransplant Infectious Diseases and Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-6757-3757
Matthew IerulloTransplant Infectious Diseases and Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.
Congrong MiaoDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
D Scott SchmidDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Stephen JuvetToronto Lung Transplant Program, University Health Network, Toronto, ON, Canada.
Atul HumarTransplant Infectious Diseases and Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.
Deepali KumarTransplant Infectious Diseases and Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.ORCID 0000-0003-1961-0477
University Health Network · CACenters for Disease Control and Prevention · USUniversity of Bern · CH

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Lung transplant recipients are at high risk for herpes zoster and preventive measures are a significant unmet need. We investigated the safety and immunogenicity of two doses of a recombinant zoster vaccine (RZV) in lung transplant recipients (≥50 years). We enrolled 50 patients of which 49 received at least one vaccine dose. Anti-glycoprotein E (gE) antibody levels (n = 43) increased significantly compared to baseline (median optical density [OD] 1.96; interquartile range [IQR]: 1.17-2.89) after the first (median OD 3.41, IQR 2.54-3.81, p < .0001) and second vaccine dose (median OD 3.63, IQR 3.39-3.86, p < .0001). gE-specific polyfunctional CD4+ T cell frequencies (n = 38) also increased from baseline (median 85 per 10

Indexed as

Herpes ZosterHerpes Zoster VaccineAntibodies, ViralHumansLungTransplant RecipientsAntibodies, ViralHerpes Zoster Vaccineclinical research/practicecomplication: infectiousinfection and infectious agents - viralinfectious diseaselung transplantation/pulmonologytranslational research/ sciencevaccine

Identifiers

PMID33565711
PMCPMC9169546
OpenAlexW3126253335

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.