Evidence map›Paper›PMID 33565583›Full record

ArticlePain medicine (Malden, Mass.)2021

Paresthesia Predicts Increased Risk of Distal Neuropathic Pain in Older People with HIV-Associated Sensory Polyneuropathy.

Monica M Diaz, John R Keltner, Alan N Simmons, Donald Franklin, Raeanne C Moore, David Clifford, Ann C Collier, Benjamin B Gelman, Ph D Christina Marra, J Allen McCutchan and 11 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain medicine (Malden, Mass.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 1 country.

Monica M DiazDepartment of Neurosciences, University of California, San Diego, La Jolla, California.ORCID 0000-0001-9663-5948
John R KeltnerCenter of Excellence in Stress and Mental Health, San Diego Veterans Health System, San Diego, California.
Alan N SimmonsCenter of Excellence in Stress and Mental Health, San Diego Veterans Health System, San Diego, California.
Donald FranklinDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Raeanne C MooreDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
David CliffordWashington University, St. Louis, Missouri.
Ann C CollierUniversity of Washington, Seattle, Washington.
Benjamin B GelmanUniversity of Texas Medical Branch, Galveston, Texas.
Ph D Christina MarraUniversity of Washington, Seattle, Washington.
J Allen McCutchanDepartment of Medicine, University of California, San Diego, La Jolla, California.
Susan MorgelloIcahn School of Medicine at Mount Sinai, New York, New York.
Ned SacktorJohns Hopkins University, Baltimore, Maryland.
Brookie BestSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California.
Christine Fennema NotestineDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Sara Gianella WeibelDepartment of Medicine, University of California, San Diego, La Jolla, California.
Igor GrantDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Thomas D MarcotteDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Florin VaidaDepartment of Family Medicine and Public Health, University of California, San Diego, La Jolla, California, USA.
Scott LetendreDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Robert HeatonDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Ronald J EllisDepartment of Neurosciences, University of California, San Diego, La Jolla, California.
University of California San Diego · USUniversity of Washington · USIcahn School of Medicine at Mount Sinai · USJohns Hopkins University · USThe University of Texas Medical Branch at Galveston · USWashington University in St. Louis · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
Texas NeuroAIDS Research CenterU24MH100930 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GELMAN, BENJAMIN B. · 2013 to 2023
$12.1M
Age related determinants of HAND: A 12 year follow-up of CHARTER participantsR01MH107345 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEATON, ROBERT KERNACHAN, LETENDRE, SCOTT L · 2015 to 2021
$7.9M
San Diego Resource Center for advancing Alzheimer's Research in Minority Seniors (ARMS)P30AG059299 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOHN P. ELDER, PAUL E GILBERT · 2018 to 2026
$7.4M
FIC NIH HHS D43 TW009343NCATS NIH HHS UL1 TR001442NIAID NIH HHS P30 AI036214NIA NIH HHS P30 AG059299NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH107345NIMH NIH HHS U24 MH100930
6 · The paper itself

Abstract

objectiveDistal sensory polyneuropathy (DSP) is a disabling consequence of human immunodeficiency virus (HIV), leading to poor quality of life and more frequent falls in older age. Neuropathic pain and paresthesia are prevalent symptoms; however, there are currently no known curative treatments and the longitudinal course of pain in HIV-associated DSP is poorly characterized.

methodsThis was a prospective longitudinal study of 265 people with HIV (PWH) enrolled in the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) study with baseline and 12-year follow-up evaluations. Since pain and paresthesia are highly correlated, statistical decomposition was used to separate the two symptoms at baseline. Multivariable logistic regression analyses of decomposed variables were used to determine the effects of neuropathy symptoms at baseline on presence and worsening of distal neuropathic pain at 12-year follow-up, adjusted for covariates.

resultsMean age was 56 ± 8 years, and 21% were female at follow-up. Nearly the entire cohort (96%) was on antiretroviral therapy (ART), and 82% had suppressed (≤50 copies/mL) plasma viral loads at follow-up. Of those with pain at follow-up (n = 100), 23% had paresthesia at the initial visit. Decomposed paresthesia at baseline increased the risk of pain at follow-up (odds ratio [OR] 1.56; 95% confidence interval [CI] 1.18, 2.07), and decomposed pain at baseline predicted a higher frequency of pain at follow-up (OR 1.96 [95% CI 1.51, 2.58]).

conclusionsParesthesias are a clinically significant predictor of incident pain at follow-up among aging PWH with DSP. Development of new therapies to encourage neuroregeneration might take advantage of this finding to choose individuals likely to benefit from treatment preventing incident pain.

Indexed as

HIV InfectionsNeuralgiaPolyneuropathiesAgedFemaleHumansLongitudinal StudiesMiddle AgedParesthesiaProspective StudiesQuality of LifeCHARTER StudyHIVNeuropathyPainParesthesia

Identifiers

PMID33565583
PMCPMC8502467
OpenAlexW3128614261

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.