ArticleACS nano2021
Failure Mechanisms in DNA Self-Assembly: Barriers to Single-Fold Yield.
Article in ACS nano, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Optimising DNA origami assembly by reducing off-target interactions.Nature communications · 2026Article
- Complex cooperativity in DNA origami revealed via design-dependent defectivity.Nucleic acids research · 2026Article
- Unraveling the Folding Dynamics of DNA Origami Structures.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Aptamers as target-specific recognition elements in drug delivery.Advanced drug delivery reviews · 2025Review
- Recycling Materials for Sustainable DNA Origami Manufacturing.Nano letters · 2024Article
- Controlling phase separations and reactions in trapped microfluidic droplets.Scientific reports · 2024Article
- Mechanism of DNA origami folding elucidated by mesoscopic simulations.Nature communications · 2024Article
- Nucleic acid nanostructures forApplied physics reviews · 2023Review
- Synthesizing the biochemical and semiconductor worlds:Nanoscale · 2022Review
- Simulations of DNA-Origami Self-Assembly Reveal Design-Dependent Nucleation Barriers.Nano letters · 2022Article
- Controllable assembly of synthetic constructs with programmable ternary DNA interaction.Nucleic acids research · 2022Article
- Best practice for improved accuracy: A critical reassessment of van't Hoff analysis of melt curves.Biophysical journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Understanding the folding process of DNA origami is a critical stepping stone to the broader implementation of nucleic acid nanofabrication technology but is notably nontrivial. Origami are formed by several hundred cooperative hybridization events-folds-between spatially separate domains of a scaffold, derived from a viral genome, and oligomeric staples. Individual events are difficult to detect. Here, we present a real-time probe of the unit operation of origami assembly, a single fold, across the scaffold as a function of hybridization domain separation-fold distance-and staple/scaffold ratio. This approach to the folding problem elucidates a predicted but previously unobserved blocked state that acts as a limit on yield for single folds, which may manifest as a barrier in whole origami assembly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.