ArticleJBRA assisted reproduction2021
Effect of Age and Embryo Morphology on Live Birth Rate After Transfer of Unbiopsied Blastocysts.
Article in JBRA assisted reproduction, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- PGT-A in POSEIDON Patients - perspectives and limitations.JBRA assisted reproduction · 2025Article
- Article
- Quality of IVM ovarian tissue oocytes: impact of clinical, demographic, and laboratory factors.Journal of assisted reproduction and genetics · 2024Article
- "Try until the last?"-the relevance of fresh embryo transfer outcomes for subsequent same-cohort vitrified-warmed cycles.Journal of assisted reproduction and genetics · 2024Article
- Serum progesterone measurement on the day of fresh embryo transfer and its correlation with pregnancy success rates: A prospective analysis.Clinics (Sao Paulo, Brazil) · 2024Article
- Blastocyst quality and reproductive and perinatal outcomes: a multinational multicentre observational study.Human reproduction (Oxford, England) · 2023Observational
- The Advantage of Growth Hormone Alone as an Adjuvant Therapy in Advanced Age and BMI ≥ 24 kg/mJournal of clinical medicine · 2023Article
- Embryo morphology and live birth in the United States.F&S reports · 2022Article
- Effect of Age and Embryo Morphology on Live Birth Rate After Transfer of Unbiopsied Blastocysts.JBRA assisted reproduction · 2021Article
- A validated model for predicting live birth after embryo transfer.Scientific reports · 2021Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the rate of live birth per blastocyst based on morphology and oocyte age using data from a single center.
methodsThis is a mathematical analysis and model building study of autologous blastocyst stage embryo transfers at a University-affiliated center. A total of 448 blastocyst stage embryos were transferred in 244 fresh and frozen embryo transfers from May 2015 through April 2018. Blastocyst morphology was divided into good, fair, and poor overall morphology grades. Each embryo transfer was modeled as an equation equating the sum of the unknown live birth rates of the transferred embryos to the number of live births that resulted. The least squares solution to the system of embryo transfer equations was determined using linear algebra.
resultsTrophectoderm morphology was a better predictor of live birth rate than inner cell mass morphology. Embryos graded AA/AB/BA (good) had the highest live birth rates followed by BB/CB (fair), and BC/CC (poor). In our youngest age group (25-32 years) live birth rates per embryo were 51% for good, 39% for fair, and 25% for poor quality embryos. In our oldest age group (40-44 years) the live birth rates per embryo were 22% for good, 14% for fair, and 8% for poor quality embryos.
conclusionsThese techniques can help analyze small datasets such as those from individual clinics to aid in determining the ideal number of embryos to transfer to achieve live birth while limiting the risk of multiple gestations.
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