Evidence map›Paper›PMID 33565274›Full record

SynthesisJournal of evidence-based medicine2021

Efficacy of surgical masks or cloth masks in the prevention of viral transmission: Systematic review, meta-analysis, and proposal for future trial.

Akriti Nanda, Ivan Hung, Ava Kwong, Vivian Chi-Mei Man, Pankaj Roy, Lucy Davies, Michael Douek

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of evidence-based medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. A systematic review andPreventive medicine reports · 2023
    Review
  5. Article
  6. Article
  7. Hidden Costs of the COVID-19 Pandemic Response.International journal of environmental research and public health · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Clinical trials in older people.Age and ageing · 2022
    Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Akriti NandaOxford University Clinical Academic Graduate School, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-7333-2730
Ivan HungDivision of Infectious Diseases, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Ava KwongDivision of Breast Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Vivian Chi-Mei ManDivision of Breast Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Pankaj RoyDepartment of Breast Surgery, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK.
Lucy DaviesSurgical Interventional Trials Unit, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Michael DouekDepartment of Breast Surgery, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK.
University of Hong Kong · HKNuffield Orthopaedic Centre · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRecommendations for widespread use of face mask, including suggested type, should reflect the current published evidence and concurrently be studied. This review evaluates the preclinical and clinical evidence on use of cloth and surgical face masks in SARS-CoV-2 transmission and proposes a trial to gather further evidence.

methodsPubMed, EMbase, and the Cochrane Library were searched. Studies of SARS-CoV-2 and face masks and randomized controlled trials (RCTs) of n ≥ 50 for other respiratory illnesses were included.

resultsFourteen studies were included in this study. One preclinical and 1 observational cohort clinical study found significant benefit of masks in limiting SARS-CoV-2 transmission. Eleven RCTs in a meta-analysis studying other respiratory illnesses found no significant benefit of masks (±hand hygiene) for influenza-like-illness symptoms nor laboratory confirmed viruses. One RCT found a significant benefit of surgical masks compared with cloth masks.

conclusionThere is limited available preclinical and clinical evidence for face mask benefit in SARS-CoV-2. RCT evidence for other respiratory viral illnesses shows no significant benefit of masks in limiting transmission but is of poor quality and not SARS-CoV-2 specific. There is an urgent need for evidence from randomized controlled trials to investigate the efficacy of surgical and cloth masks on transmission of SARS-CoV-2 and user reported outcomes such as comfort and compliance.

Indexed as

MasksTextilesCOVID-19HumansPandemicsPneumonia, ViralRandomized Controlled Trials as TopicRespiratory Tract InfectionsSARS-CoV-2COVID-19face masksSARS-CoV-2systematic reviewtrial proposal

Identifiers

PMID33565274
PMCPMC8014575
OpenAlexW3127482956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.