Observational studyActa ophthalmologica2021
Ocular pathogens and antibiotic resistance in microbial keratitis over three years in Harbin, Northeast China.
Observational study in Acta ophthalmologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Microenvironment-Responsive Drug Delivery Systems for Ocular Surface Diseases: Mechanisms, Applications, and Translational Challenges.Small science · 2026Review
- Antibiotic resistance mechanisms and global resistance patterns of Pseudomonas aeruginosa in microbial keratitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Analysis of Infectious Keratitis Isolates and Antimicrobial Resistance: An 8-Year Retrospective Study in Southern China.Antibiotics (Basel, Switzerland) · 2026Article
- The antibiotic resistance profiles of Staphylococcus in the Asia Cornea Society infectious keratitis study.International ophthalmology · 2025Article
- Characterization of infectious bacterial keratitis in Östergötland County, Sweden: a 10-year retrospective study.Journal of ophthalmic inflammation and infection · 2024Article
- The Role ofPharmaceutics · 2024Review
- Monitoring the transition from corneal ulceration to healed scar using a Scheimpflug tomography-based densitometry.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- A comparison of antimicrobial regimen outcomes and antibiogram development in microbial keratitis: a prospective cohort study in Alexandria, Egypt.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Five-year analysis of isolated pathogens and antibiotic resistance of ocular infections from two large tertiary comprehensive hospitals in east China.International journal of ophthalmology · 2024Article
- Spectrum and antibiotic sensitivity of bacterial keratitis: a retrospective analysis of eight years in a Tertiary Referral Hospital in Southwest China.Frontiers in cellular and infection microbiology · 2024Article
- Spectrum and resistance in bacterial infections of the ocular surface in a German tertiary referral center 2009-2019.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Prevalence and Antimicrobial Resistance of Causative Agents to Ocular Infections.Antibiotics (Basel, Switzerland) · 2022Article
- Comparison of 16S rDNA Amplicon Sequencing With the Culture Method for Diagnosing Causative Pathogens in Bacterial Corneal Infections.Translational vision science & technology · 2022Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeUnderstanding the spectrum of ocular pathogens in a given geographic region is important for devising appropriate practical treatment. Therefore, we examined the pathogen spectrum and antibiotic resistance of microbial keratitis in northeast China.
methodsIn this retrospective observational study, we reviewed the microbiology laboratory records of patients diagnosed with microbial keratitis in a tertiary eye hospital in Harbin, northeast China, between 2017 and 2019, and analysed the pathogen spectrum and antibiotic susceptibility.
resultsWe collected 462 specimens, of which 282 exhibited positive cultures. Among these cultures, 257 were bacterial and 25 were fungal. Of the 257 bacterial isolates, 214 (83.27%) were gram positive whereas 43 (16.73%) were gram negative. The most prevalent gram-positive pathogen was coagulase-negative staphylococcus (CoNS; 58.37%), followed by Staphylococcus aureus (S. aureus; 20.62%) and Streptococcus pneumoniae (2.33%). Of the gram-negative bacterial isolates, 10 were Pseudomonas aeruginosa (3.89%). The most frequently detected ocular pathogens from fungal isolates were Fusarium species (40%). We also found more culture-positive cases of bacterial keratitis in summer. Overall, 16.98% S. aureus and 64.00% CoNS isolates were methicillin resistant. These methicillin-resistant bacteria were also more likely to be resistant to other antibiotics, with multidrug resistance found in 77.78% methicillin-resistant S. aureus and 90.63% methicillin-resistant CoNS. However, all gram-positive isolates were sensitive to vancomycin and linezolid.
conclusionCoagulase-negative staphylococcus are the most common ocular pathogens in northeast China. We also show the prevalence of methicillin resistance and concurrent multidrug resistance among staphylococcal isolates. Monitoring the patterns of antimicrobial resistance could help in the management selection.
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