Evidence map›Paper›PMID 33565162›Full record

ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2021

Impaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis.

Shadi Yaghi, Adam de Havenon, Tristan Honda, Jason D Hinman, Radoslav Raychev, Latisha K Sharma, Song Kim, Edward Feldmann, Jose G Romano, Shyam Prabhakaran and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Shadi YaghiDepartment of Neurology, NYU Langone Health, New York, NY.ORCID 0000-0003-0031-1004
Adam de HavenonDepartment of Neurology, University of Utah, Salt Lake City, UT.ORCID 0000-0001-8178-8597
Tristan HondaDepartment of Neurology, University of California at Los Angeles, Los Angeles, CA.
Jason D HinmanDepartment of Neurology, University of California at Los Angeles, Los Angeles, CA.
Radoslav RaychevDepartment of Neurology, University of California at Los Angeles, Los Angeles, CA.
Latisha K SharmaDepartment of Neurology, University of California at Los Angeles, Los Angeles, CA.
Song KimDepartment of Neurology, University of California at Los Angeles, Los Angeles, CA.
Edward FeldmannDepartment of Neurology, University of Massachusetts Medical School, Baystate, MA.
Jose G RomanoDepartment of Neurology, University of Miami, Miami, FL.
Shyam PrabhakaranDepartment of Neurology, University of Chicago, Chicago, IL.
David S LiebeskindDepartment of Neurology, University of California at Los Angeles, Los Angeles, CA.ORCID 0000-0002-5109-8736
University of California, Los Angeles · USBaystate Medical Center · USNYU Langone Health · USUniversity of Chicago · USUniversity of Miami · USUniversity of Utah · US

Funding

Mechanisms of Early Recurrence in Intracranial Atherosclerotic DiseaseR01NS084288 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LIEBESKIND, DAVID SIGMUND, PRABHAKARAN, SHYAM · 2014 to 2018
$3.0M
Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRIK23NS105924 · NINDS · YALE UNIVERSITY · PI DE HAVENON, ADAM H. · 2019 to 2023
$988k
NINDS NIH HHS K23 NS105924NINDS NIH HHS R01 NS084288
6 · The paper itself

Abstract

background and purposePerfusion imaging can risk stratify patients with symptomatic intracranial stenosis. We aim to determine the association between perfusion delay and length of hospital stay (LOS) in symptomatic middle cerebral artery (MCA) stenosis patients.

methodsThis is a retrospective study of consecutive patients admitted to a comprehensive stroke center over 5 years with ischemic stroke or transient ischemic attack (TIA) within 7 days of symptom onset due to MCA stenosis (50-99%) and underwent perfusion imaging. Patients were divided into three groups: mismatch volume ≥ 15 cc based on T max > 6 second delay, T max 4-6 second delay, and <4 second delay. The outcome was LOS, both as a continuous variable and categorical (≥7 days [prolonged LOS] vs. <7 days). We used adjusted regression analyses to determine the association between perfusion categories and LOS.

resultsOne hundred and seventy eight of 194 patients met the inclusion criteria. After adjusting for age and NIHSS, T max >6 second mismatch was associated with prolonged LOS (OR 2.94 95% CI 1.06-8.18; P = .039), but T max 4-6 second was not (OR 1.45 95% CI .46-4.58, P = .528). We found similar associations when LOS was a continuous variable for T max > 6 second (β coefficient = 2.01, 95% CI .05-3.97, P = .044) and T max 4-6 second (β coefficient = 1.24, 95% CI -.85 to 3.34, P = .244).

conclusionIn patients with symptomatic MCA stenosis, T max > 6 second perfusion delay is associated with prolonged LOS. Prospective studies are needed to validate our findings.

Indexed as

Length of StayAgedAged, 80 and overConstriction, PathologicFemaleHumansInfarction, Middle Cerebral ArteryIschemic Attack, TransientMaleMiddle AgedMiddle Cerebral ArteryPerfusion ImagingProspective StudiesRetrospective StudiesStrokeIntracranial atherosclerosisoutcomeperfusionstroke

Identifiers

PMID33565162
PMCPMC8119309
OpenAlexW3129023014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.