ReviewEuropean journal of oral sciences2021
Application of specialized pro-resolving mediators in periodontitis and peri-implantitis: a review.
Review in European journal of oral sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immunoregulatory role of resolvins in periodontal disease and treatment: a systematic review.BMC oral health · 2026Pooled it
- Vagus nerve-mediated neuroimmune modulation for rheumatoid arthritis: a pivotal randomized controlled trial.Nature medicine · 2026Trial
- Review
- Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling.Journal of periodontal research · 2026Review
- Association of asthma and anti-asthmatic therapy with oral health and microbiota alterations in children - a cross-sectional study.BMC pediatrics · 2026Article
- Beyond receptor activation: biased toll-like receptor signaling in periodontal inflammation and regeneration.Frontiers in immunology · 2026Review
- Advances in the role of specialized pro-resolving mediators in periodontitis.Frontiers in immunology · 2026Review
- Multi-omics comparison of periodontitis and peri-implantitis identifies plasma cell enrichment as a shared feature and a periodontitis-associated endothelial-plasma cell APP-CD74 axis.Frontiers in immunology · 2026Article
- Optimizing delivery of specialized pro-resolving mediators for oral inflammation via smart hydrogels and biomaterials.Therapeutic delivery · 2025Review
- Topical Biocomposites Based on Collagen, Hyaluronic Acid and Metronidazole as Periodontitis Treatment.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Impact of Resolvin-E1 and Maresin-1 on Bone Marrow Stem Cell Osteogenesis under Inflammatory Stress.Cells · 2024Article
- Impact of Specialized Pro-Resolving Lipid Mediators on Craniofacial and Alveolar Bone Regeneration: Scoping Review.Brazilian dental journal · 2024Article
- Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis.Clinical oral investigations · 2023Article
- Recent Advances in Apical Periodontitis Treatment: A Narrative Review.Bioengineering (Basel, Switzerland) · 2023Review
- Allosteric Activation of 15-Lipoxygenase-1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Transcriptome landscape comparison of periodontium in developmental and renewal stages.Frontiers in endocrinology · 2023Article
- NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects.Frontiers in dental medicine · 2023Article
- Innovative biomaterials for the treatment of periodontal disease.Frontiers in dental medicine · 2023Review
- Resolvins as a Treatment Modality in Experimental Periodontitis: A Systematic Review of Preclinical Studies.Cureus · 2022Review
- Application of specialized pro-resolving mediators in periodontitis and peri-implantitis: a review.European journal of oral sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scaling and root planning is a key element in the mechanical therapy used for the eradication of biofilm, which is the major etiological factor for periodontitis and peri-implantitis. However, periodontitis is also a host mediated disease, therefore, removal of the biofilm without adjunctive therapy may not achieve the desired clinical outcome due to persistent activation of the innate and adaptive immune cells. Most recently, even the resident cells of the periodontium, including periodontal ligament fibroblasts, have been shown to produce several inflammatory factors in response to bacterial challenge. With increased understanding of the pathophysiology of periodontitis, more research is focusing on opposing excessive inflammation with specialized pro-resolving mediators (SPMs). This review article covers the major limitations of current standards of care for periodontitis and peri-implantitis, and it highlights recent advances and prospects of SPMs in the context of tissue reconstruction and regeneration. Here, we focus primarily on the role of SPMs in restoring tissue homeostasis after periodontal infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.