Evidence map›Paper›PMID 33565037›Full record

ArticleJournal of autism and developmental disorders2021

Profiles of Autonomic Activity in Autism Spectrum Disorder with and without Anxiety.

Valentina Parma, Nicola Cellini, Lisa Guy, Alana J McVey, Keiran Rump, Julie Worley, Brenna B Maddox, Jennifer Bush, Amanda Bennett, Martin Franklin and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Autonomic Disequilibrium at Rest in Autistic Children and Adults.Applied psychophysiology and biofeedback · 2025
    Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Valentina ParmaDepartment of Psychology, Temple University, 1701 N 13th St, Philadelphia, PA, 19122, USA. valentina.parma@temple.edu.ORCID http://orcid.org/0000-0003-0276-7072
Nicola CelliniDepartment of General Psychology, University of Padova, Via Venezia, 8, 35131, Padova, Italy.
Lisa GuyTEACCH Autism Program, University of North Carolina at Chapel Hill, Greensboro, NC, USA.
Alana J McVeyMarquette University, 604 N. 16th Street, Milwaukee, WI, 53233, USA.
Keiran RumpPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Julie WorleyPenn Foundation, Sellersville, PA, USA.
Brenna B MaddoxPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jennifer BushIndiana University, Bloomington, IN, USA.
Amanda BennettCenter for Autism Research, Children's Hospital of Philadelphia, 2716 South Street, Philadelphia, PA, 19104, USA.
Martin FranklinPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Judith S MillerCenter for Autism Research, Children's Hospital of Philadelphia, 2716 South Street, Philadelphia, PA, 19104, USA.
John HerringtonCenter for Autism Research, Children's Hospital of Philadelphia, 2716 South Street, Philadelphia, PA, 19104, USA.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USIndiana University Bloomington · USMarquette University · USUniversity of North Carolina at Chapel Hill · USUniversity of Padua · IT

Funding

TRANSGENIC MOUSE MODELS OF MENTAL RETARDATIONP30HD026979 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERTS, TIMOTHY P · 1990 to 2015
$15.3M
The fusiform and amygalda in the pathobiology of autismR01MH073084 · NIMH · YALE UNIVERSITY · PI SCHULTZ, ROBERT THOMAS · 2005 to 2009
$1.6M
National Institute of Child Health and Development P30 HD026979National Institute of Mental Health R01 MH073084-01National Institute of Mental Health RC1MH08879NICHD NIH HHS P30 HD026979NIMH NIH HHS R01 MH073084-01NIMH NIH HHS RC1MH08879Pennsylvania Department of Health 4100042728
6 · The paper itself

Abstract

Both anxiety and autism spectrum disorder (ASD) are associated with atypical physiological activity. Few studies have systematically assessed the resting physiological activity in ASD with co-occurring anxiety disorders. We tested 75 participants divided in four groups: youth with ASD, with (ASD + Anxiety = 22, 6F, 12.29 ± 2.83 years old) and without co-occurring anxiety (ASD Alone = 15, 6F, 11.59 ± 2.85 years old) and compared their physiological profile with that of matched typically developing controls (TDC) with (Anxiety Alone = 16, 6F, 11.24 ± 3.36 years old) and without co-occurring anxiety disorders (TDC = 22, 8F, 11.88 ± 2.88 years old). Results indicated reduced sympathetic and parasympathetic activity at rest in ASD as compared to TDC youth. ASD + Anxiety and Anxiety Alone groups showed different sympathetic, but similar parasympathetic activity. These findings suggest that autonomic profile-based approaches may advance research, diagnosis, and treatment of ASD and anxiety.

Indexed as

Autism Spectrum DisorderAdolescentAnxietyAnxiety DisordersAutonomic Nervous SystemChildHumansAnxiety disorderAutism spectrum disorderAutonomic profileElectrodermal activityHeart rate variability

Identifiers

PMID33565037
OpenAlexW3128742666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.