Evidence map›Paper›PMID 33564994›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2021

The variable impact of the overdose crisis on organ donation among five Canadian provinces: a retrospective study.

Sean Keenan, Andreas Kramer, Andrew Healey, Matthew J Weiss, Sonny Dhanani, Stephen Beed, Dennis Djogovic, Kathleen Sullivan, Sam D Shemie

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In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 1 country.

Sean KeenanDivision of Critical Care Medicine, Department of Medicine, University of British Columbia, Donation Services, BC Transplant, Vancouver, BC, Canada. spkeenan59@gmail.com.ORCID http://orcid.org/0000-0002-1071-4950
Andreas KramerDepartment of Critical Care Medicine & Clinical Neurosciences, University of Calgary, Southern Alberta Organ and Tissue Donation Program, Calgary, AB, Canada.
Andrew HealeyDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Matthew J WeissCHU de Québec - Université Laval Research Center, Population Health and Optimal Health Practices Research Unit, Trauma-Emergency-Critical Care Medicine, Université Laval, Québec, QC, Canada.
Sonny DhananiDivision of Critical Care, Children's Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Stephen BeedDepartment of Anesthesia and Critical Care (adult), Dalhousie University, Nova Scotia Organ and Tissue Donation Program, Halifax, NS, Canada.
Dennis DjogovicDepartment of Critical Care Medicine, University of Alberta, Human Organ Procurement and Exchange (HOPE), Edmonton, AB, Canada.
Kathleen SullivanInformation Management, Organ & Tissue Donation & Transplantation, Canadian Blood Services, Ottawa, ON, Canada.
Sam D ShemieDivision of Critical Care Medicine, Montreal Children's Hospital, MUHC Research Institute, McGill University, Deceased Organ Donation, Canadian Blood Services, Montreal, QC, Canada.
Canadian Blood Services · CADalhousie University · CAMontreal Children's Hospital · CATrillium Therapeutics (Canada) · CAUniversité Laval · CAUniversity of Alberta · CAUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile most overdose deaths in Canada occur in the community, some patients are resuscitated, admitted to intensive care units having sustained severe anoxic brain injury, and have the potential to be organ donors. The purpose of this study was to determine the impact of the overdose crisis on organ donation in selected Canadian provinces.

methodsWe obtained data on the total number of organ donors and those dying because of overdose in five Canadian provinces from 2014 to 2018. We also obtained data for January-June 2019 for four of five provinces (Quebec excepted). We accessed federal and provincial data on the number of overdose deaths and compared the proportion of organ donors who died of an overdose both over time and between provinces. The number of organ transplants resulting from donors dying of an overdose from three provinces was also determined.

resultsFrom 2014 to 2017, there was a 35% increase (554 to 747) in total deceased organ donors but a 294% increase (31 to 122) in organ donors dying of an overdose. While the proportion of organ donors dying from an overdose increased overall, this varied from 35% (42 of 121) in British Columbia to < 5% in both Quebec (9 of 182) and Nova Scotia (< 2 of 16). There were 1,043 organ transplants resulting from organ donors dying of overdose in BC, Ontario and Alberta although only 2.5-3.5% (297 of 10,858) of those dying of an overdose became organ donors.

conclusionsThere has been an increase in organ donors dying from drug overdose in Canada. Regional variation mirrors differences in total opiate-related death.

Indexed as

Drug OverdoseOrgan TransplantationTissue and Organ ProcurementAlbertaBritish ColumbiaHumansOntarioRetrospective StudiesTissue Donorsopiateorgan donationoverdose

Identifiers

PMID33564994
OpenAlexW3126818939

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.