ArticleAmerican journal of epidemiology2021
Measurement of Telomere Length for Longitudinal Analysis: Implications of Assay Precision.
Article in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- Quantile regression of the relationship between demographic factors and leukocyte telomere length, measured by Southern blot and qPCR.GeroScience · 2026Article
- There Are Multiple Clocks That Time Us: Cross-Sectional and Longitudinal Associations Among 14 Alternative Indicators of Age and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Forgiveness in Poland: Rye Forgiveness Scale Adaptation and Its Longitudinal Impact on Mental Health in HIV-Positive Individuals.Journal of clinical psychology · 2025Article
- Methods for telomere length measurement: an update on current technologies and emerging approaches.Frontiers in molecular biosciences · 2025Review
- Telomere length and mitochondrial DNA copy number in association with trauma-focused psychotherapy efficacy.Neuroscience applied · 2025Article
- Article
- The researcher's guide to selecting biomarkers in mental health studies.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
- Article
- Aging Processes Are Affected by Energy Balance: Focused on the Effects of Nutrition and Physical Activity on Telomere Length.Current nutrition reports · 2024Review
- The Social Environment Matters for Telomere Length and Internalizing Problems During Adolescence.Journal of youth and adolescence · 2024Article
- Early origins of health and disease risk: The case for investigating adverse exposures and biological aging in utero, across childhood, and into adolescence.Child development perspectives · 2023Article
- Food insecurity as a cause of adiposity: evolutionary and mechanistic hypotheses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Article
- Associations of depression and anxiety and adolescent telomere length.Psychoneuroendocrinology · 2023Article
- Healthy Lifestyle Behaviors and Biological Aging in the U.S. National Health and Nutrition Examination Surveys 1999-2018.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Genetic and clinical determinants of telomere length.HGG advances · 2023Article
- Article
- Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain.Pediatric research · 2023Article
- Peripheral Blood Telomere Attrition in Persons at Risk for Familial Pulmonary Fibrosis.American journal of respiratory and critical care medicine · 2023Article
- Transmissible cancer and longitudinal telomere dynamics in Tasmanian devils (Sarcophilus harrisii).Molecular ecology · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Researchers increasingly wish to test hypotheses concerning the impact of environmental or disease exposures on telomere length (TL), and they use longitudinal study designs to do so. In population studies, TL is usually measured with a quantitative polymerase chain reaction (qPCR)-based method. This method has been validated by calculating its correlation with a gold standard method such as Southern blotting (SB) in cross-sectional data sets. However, in a cross-section, the range of true variation in TL is large, and measurement error is introduced only once. In a longitudinal study, the target variation of interest is small, and measurement error is introduced at both baseline and follow-up. In this paper, we present results from a small data set (n = 20) in which leukocyte TL was measured twice 6.6 years apart by means of both qPCR and SB. The cross-sectional correlations between qPCR and SB were high at both baseline (r = 0.90) and follow-up (r = 0.85), yet their correlation for TL change was poor (r = 0.48). Moreover, the qPCR data but not the SB data showed strong signatures of measurement error. Through simulation, we show that the statistical power gain from performing a longitudinal analysis is much greater for SB than for qPCR. We discuss implications for optimal study design and analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.