Evidence map›Paper›PMID 33564772›Full record

ArticlebioRxiv : the preprint server for biology2021

Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography.

C Walsh, P Tafforeau, Willi L Wagner, D J Jafree, A Bellier, C Werlein, M P Kühnel, E Boller, S Walker-Samuel, J L Robertus and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 3 countries.

C WalshCentre for Advanced Biomedical Imaging, University College London, U.K.
P TafforeauEuropean Synchrotron Radiation Facility, Grenoble, France.
Willi L WagnerDept of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany Translational Lung Research Centre Heidelberg (TLRC), German Lung Research Centre (DZL), Heidelberg, Germany.
D J JafreeDevelopmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, UK.
A BellierFrench Alps Laboratory of Anatomy (LADAF), Grenoble Alpes University, Grenoble, France.
C WerleinInstitute of Pathology, Hannover Medical School, Hannover, Germany (Carl-Neuberg-Straße 1, 30625 Hannover).
M P KühnelInstitute of Pathology, Hannover Medical School, Hannover, Germany (Carl-Neuberg-Straße 1, 30625 Hannover).
E BollerEuropean Synchrotron Radiation Facility, Grenoble, France.
S Walker-SamuelCentre for Advanced Biomedical Imaging, University College London, U.K.
J L RobertusDepartment of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
D A LongDevelopmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, UK.
J JacobCentre for Medical Image Computing, University College London, London, UK.
S MarussiDepartment of Mechanical Engineering University College London, U.K.
E BrownCentre for Advanced Biomedical Imaging, University College London, U.K.
N HolroydCentre for Advanced Biomedical Imaging, University College London, U.K.
D D JonigkInstitute of Pathology, Hannover Medical School, Hannover, Germany (Carl-Neuberg-Straße 1, 30625 Hannover).
M AckermannInstitute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz.
P D LeeDepartment of Mechanical Engineering University College London, U.K.
University College London · GBMedizinische Hochschule Hannover · DEEuropean Synchrotron Radiation Facility · FRGreat Ormond Street Hospital · GBHeidelberg University · DEJohannes Gutenberg University Mainz · DERoyal Brompton & Harefield NHS Foundation Trust · GBUniversité Grenoble Alpes · FRUniversity College London Hospitals NHS Foundation Trust · GB

Funding

Adult Tissue Morphogenesis: Functional Regulation of Intussusceptive AngiogenesisR01HL094567 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MENTZER, STEVEN · 2009 to 2016
$3.2M
Formation of the Elastin Line Element in the Developing LungF32HL134229 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI VALENZUELA, CRISTIAN DAVID · 2016 to 2016
$57k
Cancer Research UK 29458Medical Research Council MR/R025673/1Medical Research Council MR/S007687/1NHLBI NIH HHS F32 HL134229NHLBI NIH HHS R01 HL094567Wellcome Trust
6 · The paper itself

Abstract

Human organs are complex, three-dimensional and multiscale systems. Spatially mapping the human body down through its hierarchy, from entire organs to their individual functional units and specialised cells, is a major obstacle to fully understanding health and disease. To meet this challenge, we developed hierarchical phase-contrast tomography (HiP-CT), an X-ray phase propagation technique utilising the European Synchrotron Radiation Facility's Extremely Brilliant Source: the world's first high-energy 4

Identifiers

PMID33564772
PMCPMC7872374
OpenAlexW3128321497

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.