Evidence map›Paper›PMID 33564689›Full record

ArticleJournal of immunology research2021

Aberrant Expression of a Proliferation-Inducing Ligand Underlies Autoimmune Mechanisms in Immune Thrombocytopenia.

Y F Hao, H Bi, H Y Li, L M Yin, J X Yu, W Tao, H L Mu, R C Yang, Z P Zhou, W L Tai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Y F HaoDepartment of Hematology, Second Affiliated Hospital of Kunming Medical University, Yunnan, Kunming 650101, China.
H BiDepartment of Hematology, Second Affiliated Hospital of Kunming Medical University, Yunnan, Kunming 650101, China.
H Y LiState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
L M YinDepartment of Hematology, Second Affiliated Hospital of Kunming Medical University, Yunnan, Kunming 650101, China.
J X YuDepartment of Hematology, Second Affiliated Hospital of Kunming Medical University, Yunnan, Kunming 650101, China.
W TaoDepartment of Hematology, Second Affiliated Hospital of Kunming Medical University, Yunnan, Kunming 650101, China.
H L MuDepartment of Hematology, Second Affiliated Hospital of Kunming Medical University, Yunnan, Kunming 650101, China.
R C YangState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Z P ZhouDepartment of Hematology, Second Affiliated Hospital of Kunming Medical University, Yunnan, Kunming 650101, China.ORCID https://orcid.org/0000-0002-7698-7695
W L TaiDepartment of Hematology, Second Affiliated Hospital of Kunming Medical University, Yunnan, Kunming 650101, China.ORCID https://orcid.org/0000-0002-8278-929X
Kunming Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo study the relationship between surface membrane-bound APRIL and ITP.

methodsThe peripheral blood of all subjects, 50 patients diagnosed with ITP and 25 healthy controls, was collected. Flow cytometry was used to detect the expression of membrane-bound APRIL on immune cells and platelets. ELISA was used to detect the content of soluble APRIL in plasma.

resultsMembrane-bound APRIL was only expressed on the surface of platelets in both ITP patients and controls. APRIL expression on the platelet surface was significantly lower in newly diagnosed (

conclusionsPlatelet surface APRIL may play a key immunoregulative role. Platelet surface APRIL is likely to be one source of the excessive serum APRIL in ITP patients. The effectiveness of treatment may be measured by determining the platelet surface APRIL levels in ITP patients.

Indexed as

AutoimmunityDisease SusceptibilityGene ExpressionAdultAgedAutoimmune DiseasesBiomarkersBlood PlateletsDisease ManagementFemaleFlow CytometryHumansMaleMiddle AgedPurpura, Thrombocytopenic, IdiopathicTreatment OutcomeBiomarkersTNFSF13 protein, humanTumor Necrosis Factor Ligand Superfamily Member 13

Identifiers

PMID33564689
PMCPMC7867467
OpenAlexW3128238840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.