Evidence map›Paper›PMID 33564585›Full record

ArticlePlastic and reconstructive surgery. Global open2021

Is the Use of Opioids Safe after Primary Cleft Palate Repair? A Systematic Review.

Percy Rossell-Perry, Carolina Romero-Narvaez, Ruth Rojas-Sandoval, Paula Gomez-Henao, Maria Pia Delgado-Jimenez, Renato Marca-Ticona

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07557576 (Comparison of Impact of Opioid and Non-Opioid Anesthesia on Pain and Agitation Levels in Children After Cleft Lip and Palate Surgery), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07557576 narecruitingnot on this mapstarted 2024, after this paper: background citation

Comparison of Impact of Opioid and Non-Opioid Anesthesia on Pain and Agitation Levels in Children After Cleft Lip and Palate Surgery

TypeinterventionalSponsorIva SmiljanićRan2024 to 2026Enrolled90ConditionsCleft Lip Palate, Orofacial Cleft, Agitation, Emergence, Analgesia AssessmentArmsKetamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg, Propofol (IV) 3-4 mg/kg, Sevoflurane (Volatile Anesthetic)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Demystifying the Suprazygomatic Maxillary Nerve Block in Paediatric Cleft Palate Surgery.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2025
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Percy Rossell-PerryEdgardo Rebagliatti Hospital, Lima, Peru.
Carolina Romero-NarvaezSan Bartolome Mother and Children Hospital, Lima, Peru.
Ruth Rojas-SandovalDepartment of Anesthesiology of National Institute of Children, Lima, Peru.
Paula Gomez-HenaoService of Anesthesiology, National Institute of Cancer, Bogota, Colombia.
Maria Pia Delgado-JimenezEdgardo Rebagliatti Hospital, Lima, Peru.
Renato Marca-TiconaSan Bartolome Mother and Children Hospital, Lima, Peru.
Hospital Nacional Cayetano Heredia · PEInstituto Nacional de Salud del Niño · PEInstituto Nacional de Cancerología · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmacologic treatment of postoperative pain after cleft palate repair includes opioids and nonopioid analgesics, nerve blocks, and local anesthetic infiltration. Use of opioids in infants has concerns regarding sedation, risk of aspiration, respiratory depression, and respiratory distress. The main objective of this review was to analyze information available on the safety of the use of opioids during perioperative management of pain related to primary cleft palate repair in published studies.

methodsA systematic review of the literature for studies published until March 2020 was performed to evaluate the safety of opioid drugs during primary cleft palate repair pain management. The authors chose the following MesH terms for this systematic review: cleft lip and palate AND opioids AND pain management. The investigators performed a systematic literature search using the Pubmed/MEDLINE, Embase, Web of Science, and Cochrane Library databases.

resultsAfter a literature search resulting in 70 identified studies, 9 were qualified for the final analysis, which included 772 patients. There was a high level of evidence in the selected studies according to the Oxford CEBM Level of Evidence classification and GRADE scale. The most common adverse event reported was postoperative nausea and vomiting (from 5% to 25%). Episodes of oxygen desaturation have been reported from 2.5% to 7.4% of the studied patients.

conclusions: Definitive conclusions about the safety of opioid drugs during primary cleft palate repair pain management cannot be drawn. Vomiting and oxygen desaturation have been associated with the use of opioids in the studied population.

Identifiers

PMID33564585
PMCPMC7858197
OpenAlexW3124838687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.