Evidence map›Paper›PMID 33564563›Full record

ArticleIEEE access : practical innovations, open solutions2020

Exploring Uncertainty Measures in Bayesian Deep Attentive Neural Networks for Prostate Zonal Segmentation.

Yongkai Liu, Guang Yang, Melina Hosseiny, Afshin Azadikhah, Sohrab Afshari Mirak, Qi Miao, Steven S Raman, Kyunghyun Sung

Open access · goldAbstract read
In one paragraph

Article in IEEE access : practical innovations, open solutions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

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  15. Unified Focal loss: Generalising Dice and cross entropy-based losses to handle class imbalanced medical image segmentation.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yongkai LiuDepartment of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Guang YangNational Heart and Lung Institute, Imperial College London, South Kensington, London, UK, SW7 2AZ.
Melina HosseinyDepartment of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Afshin AzadikhahDepartment of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Sohrab Afshari MirakDepartment of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Qi MiaoDepartment of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Steven S RamanDepartment of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Kyunghyun SungDepartment of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · USLung Institute · US

Funding

Integrating Quantitative MRI and Artificial Intelligence to Improve Prostate Cancer ClassificationR01CA248506 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUNG, KYUNG HYUN, WU, HOLDEN H · 2020 to 2024
$3.0M
NCI NIH HHS R01 CA248506
6 · The paper itself

Abstract

Automatic segmentation of prostatic zones on multiparametric MRI (mpMRI) can improve the diagnostic workflow of prostate cancer. We designed a spatial attentive Bayesian deep learning network for the automatic segmentation of the peripheral zone (PZ) and transition zone (TZ) of the prostate with uncertainty estimation. The proposed method was evaluated by using internal and external independent testing datasets, and overall uncertainties of the proposed model were calculated at different prostate locations (apex, middle, and base). The study cohort included 351 MRI scans, of which 304 scans were retrieved from a de-identified publicly available datasets (PROSTATEX) and 47 scans were extracted from a large U.S. tertiary referral center (external testing dataset; ETD)). All the PZ and TZ contours were drawn by research fellows under the supervision of expert genitourinary radiologists. Within the PROSTATEX dataset, 259 and 45 patients (internal testing dataset; ITD) were used to develop and validate the model. Then, the model was tested independently using the ETD only. The segmentation performance was evaluated using the Dice Similarity Coefficient (DSC). For PZ and TZ segmentation, the proposed method achieved mean DSCs of 0.80±0.05 and 0.89±0.04 on ITD, as well as 0.79±0.06 and 0.87±0.07 on ETD. For both PZ and TZ, there was no significant difference between ITD and ETD for the proposed method. This DL-based method enabled the accuracy of the PZ and TZ segmentation, which outperformed the state-of-art methods (Deeplab V3+, Attention U-Net, R2U-Net, USE-Net and U-Net). We observed that segmentation uncertainty peaked at the junction between PZ, TZ and AFS. Also, the overall uncertainties were highly consistent with the actual model performance between PZ and TZ at three clinically relevant locations of the prostate.

Indexed as

Attentive modulesAutomatic SegmentationBayesian Deep LearningProstate Zones

Identifiers

PMID33564563
PMCPMC7869831
OpenAlexW3071727253

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.