ArticleWorld journal of gastrointestinal pharmacology and therapeutics2021
Increased colon transit time and faecal load in irritable bowel syndrome.
Article in World journal of gastrointestinal pharmacology and therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Comparative Analysis of Gut Microbiota in Patients with Irritable Bowel Syndrome and Healthy Controls.Journal of clinical medicine · 2025Article
- Moving beyond Symptom Criteria to Diagnose and Treat Functional Disorders: Patient-Reported Symptoms of Functional Lower Gastrointestinal Disorders Correlate Poorly with Objective Assessment of Luminal Contents Seen on Intestinal Ultrasound.Journal of clinical medicine · 2024Article
- Tannins-Based Extracts: Effects on Gut Chicken Spontaneous Contractility.Molecules (Basel, Switzerland) · 2023Article
- Review
- Targeting Mechano-Transcription Process as Therapeutic Intervention in Gastrointestinal Disorders.Frontiers in pharmacology · 2021Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIrritable bowel syndrome (IBS) is a bowel disorder involving abdominal pain or discomfort along with irregularity of stool form and passage frequency. The pathophysiology is poorly understood and seems to be multifactorial. Investigations of possible causes of IBS have included only a few colonic transit studies and no simultaneous determination of the colonic faecal content.
aimTo compare colon transit time and faecal load between IBS-patients and healthy control subjects.
methodsThe study included 140 patients with IBS, with a mean age of 50.0 years. The control group comprised 44 healthy persons with a mean age of 43.4 years, who were selected at random from the National Civil Register. Both the patient group and the control group underwent a marker study to measure colon transit time (CTT) and to calculate a faecal loading score. The patient group underwent treatment with a combined prokinetic regime, after which their CTT and faecal loading were reassessed. Analyses were performed to compare measurements between the control group and the patient group before and after treatment.
resultsCompared to healthy controls, IBS-patients exhibited a significantly prolonged mean CTT (45.48 h
conclusionIBS-patients exhibited prolonged CTT and heavier faecal loading. These assessments may aid in diagnosis. Faecal retention may contribute to IBS symptoms, which can be treated using a prokinetic regime.
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