ArticleClinical kidney journal2021
Predicting mortality risk on dialysis and conservative care: development and internal validation of a prediction tool for older patients with advanced chronic kidney disease.
Article in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-term Outcomes Among Patients With Advanced Kidney Disease Who Forgo Maintenance Dialysis: A Systematic Review.JAMA network open · 2022Pooled it
- Dialysis versus conservative kidney management in older adults: why one size does not fit all.International urology and nephrology · 2026Review
- Nomogram predicting 2 year overall survival in dialysis patients with lower extremity peripheral arterial disease after endovascular therapy: a multicenter prospective cohort study.Cardiovascular intervention and therapeutics · 2025Article
- Development and Validation of Survival Scores and the Assessment of Spatial Trends in End-Stage Kidney Disease Outcomes.Research square · 2025Article
- Development and validation of a prediction model for all-cause mortality in maintenance dialysis patients: a multicenter retrospective cohort study.Renal failure · 2024Article
- How to make a shared decision with older persons for end-stage kidney disease treatment: the added value of geronto-nephrology.Clinical kidney journal · 2024Review
- Machine Learning to Predict the Need for Postmastectomy Radiotherapy after Immediate Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2024Article
- Development of a prognostic risk score to predict early mortality in incident elderly Japanese hemodialysis patients.PloS one · 2024Article
- Predicting outcomes in chronic kidney disease: needs and preferences of patients and nephrologists.BMC nephrology · 2023Article
- Ageing meets kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Article
- Ageing meets kidney disease.Clinical kidney journal · 2022Article
- Article
- Physical Resilience Phenotype Trajectories in Incident Hemodialysis: Characterization and Mortality Risk Assessment.Kidney international reports · 2022Article
- Communication principles and practices for making shared decisions about renal replacement therapy: a review of the literature.Current opinion in nephrology and hypertension · 2021Review
- [Prognosis of in hospital nonagenarians with acute kidney injury].Anales del sistema sanitario de Navarra · 2021Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundConservative care (CC) may be a valid alternative to dialysis for certain older patients with advanced chronic kidney disease (CKD). A model that predicts patient prognosis on both treatment pathways could be of value in shared decision-making. Therefore, the aim is to develop a prediction tool that predicts the mortality risk for the same patient for both dialysis and CC from the time of treatment decision.
methodsCKD Stage 4/5 patients aged ≥70 years, treated at a single centre in the Netherlands, were included between 2004 and 2016. Predictors were collected at treatment decision and selected based on literature and an expert panel. Outcome was 2-year mortality. Basic and extended logistic regression models were developed for both the dialysis and CC groups. These models were internally validated with bootstrapping. Model performance was assessed with discrimination and calibration.
resultsIn total, 366 patients were included, of which 126 chose CC. Pre-selected predictors for the basic model were age, estimated glomerular filtration rate, malignancy and cardiovascular disease. Discrimination was moderate, with optimism-corrected C-statistics ranging from 0.675 to 0.750. Calibration plots showed good calibration.
conclusionsA prediction tool that predicts 2-year mortality was developed to provide older advanced CKD patients with individualized prognosis estimates for both dialysis and CC. Future studies are needed to test whether our findings hold in other CKD populations. Following external validation, this prediction tool could be used to compare a patient's prognosis on both dialysis and CC, and help to inform treatment decision-making.
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