Evidence map›Paper›PMID 33564409›Full record

ReviewClinical kidney journal2021

Management of patients with a failed kidney transplant: what should we do?

Marco Fiorentino, Pasquale Gallo, Marica Giliberti, Vincenza Colucci, Antonio Schena, Giovanni Stallone, Loreto Gesualdo, Giuseppe Castellano

Open access · goldAbstract readReview
In one paragraph

Review in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marco FiorentinoDepartment of Emergency and Organ Transplantation, "Aldo Moro" University, Bari, Italy.
Pasquale GalloDepartment of Emergency and Organ Transplantation, "Aldo Moro" University, Bari, Italy.
Marica GilibertiDepartment of Emergency and Organ Transplantation, "Aldo Moro" University, Bari, Italy.
Vincenza ColucciDepartment of Emergency and Organ Transplantation, "Aldo Moro" University, Bari, Italy.
Antonio SchenaDepartment of Emergency and Organ Transplantation, "Aldo Moro" University, Bari, Italy.
Giovanni StalloneNephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Science, University of Foggia, Foggia, Italy.
Loreto GesualdoDepartment of Emergency and Organ Transplantation, "Aldo Moro" University, Bari, Italy.
Giuseppe CastellanoNephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Science, University of Foggia, Foggia, Italy.ORCID 0000-0002-0153-3795
University of Bari Aldo Moro · ITUniversity of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The number of kidney transplant recipients returning to dialysis after graft failure is steadily increasing over time. Patients with a failed kidney transplant have been shown to have a significant increase in mortality compared with patients with a functioning graft or patients initiating dialysis for the first time. Moreover, the risk for infectious complications, cardiovascular disease and malignancy is greater than in the dialysis population due to the frequent maintenance of low-dose immunosuppression, which is required to reduce the risk of allosensitization, particularly in patients with the prospect of retransplantation from a living donor. The management of these patients present several controversial opinions and clinical guidelines are lacking. This article aims to review the leading evidence on the main issues in the management of patients with failed transplant, including the ideal timing and modality of dialysis reinitiation, the indications for an allograft nephrectomy or the correct management of immunosuppression during graft failure. In summary, retransplantation is a feasible option that should be considered in patients with graft failure and may help to minimize the morbidity and mortality risk associated with dialysis reinitiation.

Indexed as

allograft nephrectomyallosensitizationdialysisgraft failureimmunosuppressionretransplantation

Identifiers

PMID33564409
PMCPMC7857798
OpenAlexW3042894602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.