Evidence map›Paper›PMID 33564242›Full record

ArticleOncoTargets and therapy2021

Bone Marrow Mesenchymal Stem Cells-Derived Extracellular Vesicles Promote Proliferation, Invasion and Migration of Osteosarcoma Cells via the lncRNA MALAT1/miR-143/NRSN2/Wnt/β-Catenin Axis.

Fujiang Li, Xin Chen, Cong Shang, Qinglong Ying, Xianjun Zhou, Rongkun Zhu, Hongting Lu, Xiwei Hao, Qian Dong, Zhong Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  5. Osteosarcoma in a ceRNET perspective.Journal of biomedical science · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Fujiang LiDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
Xin ChenDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
Cong ShangDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
Qinglong YingDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
Xianjun ZhouDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
Rongkun ZhuDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
Hongting LuDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
Xiwei HaoDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
Qian DongDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
Zhong JiangDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.ORCID 0000-0001-8352-7526
Qingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOsteosarcoma is a malignant primary bone tumor. Bone marrow-derived mesenchymal stem cells-derived extracellular vesicles (BMSC-EVs) bear repair function for bone and cartilage. This study investigated the mechanism of BMSC-EVs in osteosarcoma cell proliferation, migration and invasion.

methodsBMSC-EVs were isolated and identified. The effects of different concentrations of EVs on osteosarcoma cell proliferation, migration and invasion were evaluated. LncRNA MALAT1 expression in osteosarcoma cells was detected. BMSCs were transfected with si-MALAT1 or si-NC. The binding relationships between MALAT1 and miR-143, and miR-143 and NRSN2 were verified. Levels of NRSN2 and Wnt/β-catenin pathway key proteins were detected. miR-143 mimic was transfected into EVs-treated osteosarcoma cells. Nude mice were injected with MG63 cells to verify the effect of EVs on osteosarcoma growth in vivo.

resultsBMSC-EVs facilitated proliferation, invasion and migration of osteosarcoma cells. BMSC-EVs carried MALAT1 into osteosarcoma cells. BMSC-EVs-treated osteosarcoma cells showed increased MALAT1 and NRSN2 expressions, decreased miR-143 expression, and activated Wnt/β-catenin pathway. miR-143 mimic or si-MALAT1 reversed the effects of BMSC-EVs on osteosarcoma cells. In vivo experiment confirmed that BMSC-EVs promoted tumor growth in nude mice. DISCUSSION: BMSC-EVs promoted proliferation, invasion and migration of osteosarcoma cells via the MALAT1/miR-143/NRSN2/Wnt/β-catenin axis. This study might offer new insights into osteosarcoma management.

Indexed as

bone marrow-derived mesenchymal stem cellsextracellular vesicleslncRNA MALAT1miR-143NRSN2osteosarcomaWnt/β-catenin pathway

Identifiers

PMID33564242
PMCPMC7866913
OpenAlexW3127975590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.