ArticleJournal of perinatology : official journal of the California Perinatal Association2021
The use of intramuscular glucagon to prevent IV glucose infusion in early neonatal hypoglycemia.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Oral dextrose gel for hypoglycemia in a well-baby nursery: a baby-friendly initiative.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Neonatal hypoglycaemia.BMJ medicine · 2024Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the success rate of intramuscular (IM) glucagon in preventing need for IV glucose and describe its glycemic effect.
methodsRetrospective study of 158 consecutive term neonates with feeding-resistant hypoglycemia treated with glucagon.
resultsAfter glucagon, blood glucose (BG) increased in all but 1 infant by 25.9 ± 17.1, 42.1 ± 21.1, and 39.2 ± 28.3 mg/dL (1.4 ± 0.9, 2.3 ± 1.2, 2.2 ± 1.6 mmol/L) at 30, 60 and 120 mins respectively. In multivariable logistic regression, glucagon success was dependent upon gender (increased male risk) (P = 0.021), meeting American Academy of Pediatrics (AAP) criteria for immediate IV glucose (P = 0.004), birth weight, (P = 0.018) and delta glucose concentration at 60 min (P = 0.013). After IM glucagon, 24 out of 49 infants that met AAP criteria for immediate IV glucose (49%) ended up not requiring any additional intervention.
conclusionsGlucagon increases BG nearly universally in hypoglycemic infants and allowed reducing the number of infants that needed immediate IV glucose infusion therapy by ≈half.
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Registered trials
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