Evidence map›Paper›PMID 33564083›Full record

ArticleJournal of human genetics2021

ALOX12 mutation in a family with dominantly inherited bleeding diathesis.

Tetsuo Mitsui, Satoshi Makino, Gen Tamiya, Hiroko Sato, Yuki Kawakami, Yoshitaka Takahashi, Toru Meguro, Hiroko Izumino, Yosuke Sudo, Ikuo Norota and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of human genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Tetsuo MitsuiDepartment of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan. tmitsui@med.id.yamagata-u.ac.jp.
Satoshi MakinoTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Gen TamiyaTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. gtamiya@genetix-h.com.
Hiroko SatoDepartment of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
Yuki KawakamiDepartment of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama, Japan.
Yoshitaka TakahashiDepartment of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama, Japan.
Toru MeguroDepartment of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
Hiroko IzuminoDepartment of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
Yosuke SudoDepartment of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
Ikuo NorotaDepartment of Pharmacology, Yamagata University School of Medicine, Yamagata, Japan.
Kuniaki IshiiDepartment of Pharmacology, Yamagata University School of Medicine, Yamagata, Japan.
Kiyoshi HayasakaDepartment of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan. hayasaka@med.id.yamagata-u.ac.jp.
Yamagata University · JPOkayama Prefectural University · JPTohoku Medical Megabank Organization · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The arachidonic acid (AA) cascade plays a significant role in platelet aggregation. AA released from membrane phospholipids is metabolized by cyclooxygenase (COX) pathway to thromboxane A

Indexed as

Genetic Predisposition to Disease15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidArachidonate 12-LipoxygenaseArachidonic AcidBlood Coagulation Disorders, InheritedBlood PlateletsCalciumDisease SusceptibilityGTP PhosphohydrolasesHemorrhageHigh-Throughput Nucleotide SequencingHumansInositol 1,4,5-TrisphosphateMutationPedigreePhospholipase C beta15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidALOX12 protein, humanArachidonate 12-LipoxygenaseArachidonic AcidCalciumGTP PhosphohydrolasesInositol 1,4,5-TrisphosphatePhospholipase C betaPLCB2 protein, humanProstaglandin-Endoperoxide SynthasesThromboxane A2

Identifiers

PMID33564083
OpenAlexW3126523744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.